Translational role of molecular biomarkers in developing targeted therapies for central nervous system tumors.

Jaishriram Rathored, Tanushree Budhbaware, Sushma Chauhan, Mithlesh Kumar

Abstract readReview

In one paragraph

Review in IBRO neuroscience reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Circulating Tumor Cells: Isolation, Preclinical Models, and Clinical Applications for Personalized Cancer Therapy.Biomolecules · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jaishriram RathoredCentral Research Laboratory and Molecular Diagnostics, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra 442001, India.

Tanushree BudhbawareCentral Research Laboratory and Molecular Diagnostics, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra 442001, India.

Sushma ChauhanAmity Institute of Biotechnology, Amity University, Raipur, Chhattisgarh 493221, India.

Mithlesh KumarCentral Research Laboratory and Molecular Diagnostics, School of Allied Health Sciences, Datta Meghe Institute of Higher Education and Research, Sawangi (Meghe), Wardha, Maharashtra 442001, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The identification of biomarkers has led to the discovery of new pathways for precision diagnostics and tailored therapies in neoplasms of the central nervous system, thereby enhancing prognoses due to their diverse anatomical structures. Objective: This review explores advancements in identifying biomarkers in central nervous system tumors and their application in targeted therapeutic strategies. Methods: The literature review, utilizing electronic databases like PubMed, Scopus, and Web of Science, emphasized studies on CNS tumors, biomarkers, targeted therapy, and precision medicine, emphasizing clinical trials, validation of biomarkers, and molecular characterization. Discussion: Advances in liquid biopsy and sequencing have significantly impacted the diagnosis and prognosis of CNS malignancies, leading to targeted therapies and improved biomarker discovery. Conclusion: Biomarker-driven approaches have significantly improved CNS cancer treatment. Future research should focus on confirming new biomarkers, improving delivery methods, and ensuring wider access to precision drugs to improve patient lifespan and quality of life.

Indexed as

BiomarkersCentral nervous system tumorsPrecision medicineTargeted therapyTranslational researchTumor heterogeneity

Identifiers

PMID41311621

DOI10.1016/j.ibneur.2025.11.006

PMCPMC12651779

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.