Evidence map›Paper›PMID 41311797›Full record

ArticleFrontiers in nutrition2025

Associations of single and multiple vitamin levels with pediatric oral mucosal diseases: a cross-sectional study with multi-model analysis.

Panpan Fang, Yingyuan Wang, Nan Chen, Kaijie Gao, Liu Yang, Xuchen Wang, Ci Li, Qianqian Sun, Tiewei Li, Junmei Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Panpan FangZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Yingyuan WangDepartment of Neonatal Intensive Care Unit, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Nan ChenZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Kaijie GaoZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Liu YangZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Xuchen WangZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Ci LiZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Qianqian SunZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Tiewei LiZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Junmei YangZhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Henan Children's Hospital, Zhengzhou Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vitamins play a crucial role in children's oral health, yet the associations between multiple vitamins and pediatric oral mucosal diseases (OMDs) remain unclear. Existing studies often focus on single vitamin, leaving gaps in understanding the complex interactions of vitamin mixtures on OMDs and age-specific effects. Methods: This cross-sectional study included 1,287 children from the Children's Hospital Affiliated to Zhengzhou University (January 2022 to April 2025), comprising 167 OMDs patients and 1,120 healthy controls. Participants were stratified into early childhood (0-6 years; Results: Our analyses consistently revealed a significant inverse association between vitamin mixtures and OMDs prevalence across all age groups ( Conclusion: This study reveals that vitamin mixtures reduce OMDs risk in children. Vitamin B6 exhibited a U-shaped relationship, protective at moderate levels. Age-specific effects were observed: vitamin E inversely and vitamin B9 positively associated with OMDs exclusively in early childhood.

Indexed as

early childhoodoral mucosal diseasesschool-age childrenvitaminvitamin mixtures

Identifiers

PMID41311797
PMCPMC12648972

What Socratic holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.