Evidence mapPaperPMID 41311802Full record

ArticleFrontiers in nutrition2025

Atherosclerosis index and BMI: new predictors of cognitive function in ischemic survivors.

Lingyan Zhao, Chenyang Qin, Hanbo Yu, Luofan Zhang, Dingchen Zhang, Shu Wang, Guiping Li

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Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Lingyan Zhao *First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Chenyang Qin *First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Hanbo YuFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Luofan ZhangFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Dingchen ZhangFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Shu WangTianjin Academy of Traditional Chinese Medicine Affiliated Hospital, Tianjin, China.
Guiping LiFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The atherogenic index of plasma (AIP) is a reliable surrogate marker for insulin resistance and is strongly associated with both stroke risk and prognosis. However, the associations of AIP and the composite index AIP-BMI with cognitive function among patients with ischemic stroke remain insufficiently studied. Methods: This cross-sectional study included 2,933 patients with ischemic stroke. Demographic and clinical data were collected from all participants. The AIP was calculated as log [TG (mmol/L)/HDL-C (mmol/L)], and cognitive function was evaluated using the Mini-Mental State Examination (MMSE). Multivariable linear regression models were applied to examine the associations between AIP (and AIP-BMI) and MMSE scores, adjusting for potential confounders. Stratified and sensitivity analyses were further conducted to evaluate the robustness of the findings. Results: The mean age of participants was 64.8 years (SD 10.2), and 2,009 (68.5%) were male. Each one-unit increase in AIP was associated with a 1.15-point reduction in MMSE score ( Conclusion: Higher levels of AIP and AIP-BMI are independently associated with poorer cognitive performance in patients with ischemic stroke. These findings suggest that dyslipidemia-related metabolic disturbances may contribute to post-stroke cognitive impairment. Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=120858, identifier ChiCTR2100042721.

Indexed as

atherogenic index of plasmacognitive functioninsulin resistanceischemic strokemetabolism

Identifiers

PMID41311802
PMCPMC12648598

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.