Evidence map›Paper›PMID 41311805›Full record

ArticleFrontiers in nutrition2025

Different association between triglyceride-glucose index and mild cognitive impairment in type 2 diabetes mellitus patients with and without diabetic kidney disease.

Songtao Feng, Zhen Zhang, Qingyue Gao, Ling Huang, Ya Zhang, Mengting He, Bing Song, Wenwen Zhu, Li Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Songtao Feng *Department of Nephrology, Jiangsu University Affiliated People's Hospital, Zhenjiang, China.
Zhen Zhang *Department of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Qingyue Gao *Department of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Ling HuangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Ya ZhangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Mengting HeDepartment of Endocrinology and Metabolism, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Bing SongDepartment of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.
Wenwen ZhuDepartment of Endocrinology, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, China.
Li DingDepartment of Endocrinology, Taikang Xianlin Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: The triglyceride-glucose (TyG) index, a surrogate marker reflecting metabolic status related to both glucose and lipid homeostasis, has been implicated in the development of diabetes-related complications, including diabetic kidney disease (DKD). Metabolic disturbances in carbohydrate and lipid pathways have also been linked to impairments in cognitive performance. This study aims to explore the association between TyG levels and the presence of mild cognitive impairment (MCI) among individuals with type 2 diabetes mellitus (T2DM), stratified by DKD status. Methods: A total of 243 patients with T2DM were divided into two subgroups based on cognitive status: those with MCI and those without. Clinical parameters were assessed and compared between the two cohorts. The association between TyG index and cognitive function was analyzed. Furthermore, potential predictors of MCI were explored separately in T2DM patients with and without DKD. Results: In individuals with T2DM, those exhibiting MCI ( Conclusion: Elevated TyG index levels have been linked to an increased likelihood of MCI, particularly affecting executive function and immediate recall, among individuals with T2DM but without DKD.

Indexed as

diabetic complicationdiabetic kidney diseasemild cognitive impairmenttriglyceride-glucose indextype 2 diabetes mellitus

Identifiers

PMID41311805
PMCPMC12649707

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.