ReviewFrontiers in bioengineering and biotechnology2025
Advances in 3D-Printed scaffolds for bone defect repair: material strategies and synergistic functional performance.
Review in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Natural Polymers in Guided Bone Regeneration (GBR).Journal of functional biomaterials · 2026Review
- Stimuli-responsive 4D-bioprinted constructs for musculoskeletal tissue regeneration: Shape-morphing mechanisms, cell-laden bioink engineering, and preclinical outcomes.Regenerative therapy · 2026Review
- From structural complexity to circular applications: a comparative review of the enzymatic degradation of polydopamine, tannins, lignins, and melanins.RSC advances · 2026Review
- Multifunctional 3D-Printed Titanium Alloy Composite-Coated Scaffold for Modulating the Immune Microenvironment and Promoting Osteogenesis.ACS applied materials & interfaces · 2026Article
- Biomimetic Chitosan/Polyvinyl Alcohol-Glycerol Scaffolds Inspired by Porcupine Quills for Segmental Bone Defect Repair.Journal of functional biomaterials · 2026Article
- Calcium Phosphate Nanostructured Biocomposites with Applications in Bone Tissue Engineering.Materials (Basel, Switzerland) · 2026Review
- Treatment of femoral defects in rats with collagen and elastin polymers combined with hydroxyapatite and bone morphogenetic protein.Frontiers in bioengineering and biotechnology · 2026Article
- Strontium-Functionalized Biomaterials for Bone Regeneration: Mechanisms, Biological Functions, and Clinical Translational Progress.International journal of nanomedicine · 2026Review
- Cross-Disciplinary Mechanistic Insights in Molecular Medicine.Current issues in molecular biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large bone defects remain a major clinical challenge, as traditional grafts and implants often fail to provide both long-term stability and biological integration. Three-dimensional (3D) printing offers unique advantages in fabricating patient-specific scaffolds with controlled architectures, enabling precise modulation of mechanics, degradation, and biological function. Natural and synthetic polymers, ceramics, and their composites have been widely explored, while strategies such as nanofiller reinforcement, surface modification, and growth-factor delivery further enhance osteogenesis, angiogenesis, immunomodulation, and anti-infection performance. This review systematically summarizes recent progress in 3D-printed biomaterial scaffolds for bone defect repair, focusing on their mechanical properties, degradation behavior, bioactivity, infection resistance, and vascularization. Current advances highlight how multifunctional design and material-biological coupling can bridge the gap between laboratory research and translational applications. Future directions emphasize material innovation, hierarchical scaffold design, and clinical standardization to accelerate the safe and effective application of 3D-printed scaffolds in bone regeneration.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.