Evidence map›Paper›PMID 41311990›Full record

ReviewFrontiers in human neuroscience2025

Precision neurodiversity: personalized brain network architecture as a window into cognitive variability.

Suleiman Ibrahim Mohammad, Eman Raeed Azzam, Asokan Vasudevan, Sayed M Ismail, Hina Ayaz, K D V Prasad

Abstract readReview
In one paragraph

Review in Frontiers in human neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Suleiman Ibrahim MohammadElectronic Marketing and Social Media, Economic and Administrative Sciences Zarqa University, Zarqa, Jordan.
Eman Raeed AzzamMedical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-maarif, Anbar, Iraq.
Asokan VasudevanFaculty of Business and Communications, INTI International University, Nilai, Negeri Sembilan, Malaysia.
Sayed M IsmailDepartment of English Language and Literature, College of Science and Humanities, Prince Sattam Bin Abdulaziz University, Al-kharj, Saudi Arabia.
Hina AyazDepartment of Psychology, Hamdard University, Karachi, Pakistan.
K D V PrasadSymbiosis Institute of Business Management, Hyderabad, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precision neurodiversity marks a shift in neuroscience from pathological models to personalized frameworks that view neurological differences as adaptive variations. This review synthesizes current knowledge on the Personalized Brain Network architecture and its relationship with cognitive variability in both typical and neurodiverse populations. The study examines advancements in connectome-based prediction modeling, normative modeling, dynamic fingerprinting, and machine learning methods that characterize individual-specific neural networks. Recent findings indicate that the Personalized Brain Network profile reliably predicts cognitive, behavioral, and sensory phenomena. Additionally, deep generative models demonstrate high fidelity in synthesizing connective cells. Recent studies have identified distinct neurobiological subgroups in conditions such as attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder that were previously undetectable by conventional diagnostic criteria. However, research has revealed significant network-level differences among these subgroups. Researchers have identified age-resistant biomarkers in specific brain regions, and genetic mutations significantly influence the connectivity patterns of individuals. Clinical applications span a range of neurodevelopmental conditions, including autism, ADHD, dyslexia, and talent. Network variability predicts executive functioning, social perception, and sensory processing abilities. However, successful translation requires overcoming challenges related to statistical power, reproducibility, ethical implementation and community participation. The convergence of advanced neuroimaging, artificial intelligence, and personalized medicine offers unprecedented opportunities for tailored interventions, while celebrating neurological diversity as a source of human strength.

Indexed as

brain connectomemachine learningmagnetic resonance imagingneurodevelopmental disordersneurodiversityprecision medicine

Identifiers

PMID41311990
PMCPMC12647089

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.