ArticleCurrent opinion in systems biology2025
Structural and practical identifiability of within-host models of virus dynamics - a review.
Article in Current opinion in systems biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Investigation of a Two-Patch Within-Host Model of Hepatitis B Viral Infection.Bulletin of mathematical biology · 2025Article
- From Bird Viremia to Bird Surveillance: Identifiability in a Multiscale Vector-Borne Model of Usutu Virus Infection.bioRxiv : the preprint server for biology · 2025Article
- Calibrated Ecosystem Models Cannot Predict the Consequences of Conservation Management Decisions-Clarification.Ecology letters · 2025Article
- Inference and prediction for stochastic models of biological populations undergoing migration and proliferation.Journal of the Royal Society, Interface · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Within-host mechanistic mathematical models of virus dynamics described by ordinary differential equations are most useful when linked to empirical data. The main challenge in estimating parameters from typically available, noisy data arises from the intrinsic parameter correlations induced by model structure. As a result, the optimization problem, which fits parameters by minimizing the distance between the model and the data, may admit infinitely many solutions. These challenges can be elucidated through the study of structural and practical identifiability of the proposed model. In this article, we review existing methods for the structural and practical identifiability of the basic within-host model of viral dynamics and provide guidelines for improving unidentifiability. We discuss the challenges and new developments in extending these techniques to non-ordinary within-host differential equation models (delay, partial, and stochastic) and stress the importance of using practical identifiability results to guide optimal experimental design.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.