Evidence map›Paper›PMID 41312958›Full record

ArticleMolecular pain

Single cell transcriptomic analysis reveals dynamic cellular composition changes at acupuncture point BL23 (Shenshu) in low back pain.

Gexin Zhao, Xiuju Wu, Shunfa Huang, Shihui Huang, Guodong Zhang, Xin Zhou, Shengqi Cao, Hyun-Ju Lim, Mark I Ii Duhon, Rui Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pain. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gexin ZhaoDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, UCLA Technology Center for Genomics & Bioinformatics, Los Angeles, CA, USA.ORCID 0000-0003-2278-3432
Xiuju WuDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Shunfa HuangZuo Cheng Acupuncture Clinic, San Gabriel, CA, USA.
Shihui HuangChinatown Service Center Health, Monterey Park, CA, USA.
Guodong ZhangArcadia Clinic, Arcadia, CA, USA.
Xin ZhouQiqihaer First Hospital, Qiqihar, Heilongjiang, China.
Shengqi CaoBC Acupro LLC., Buena Park, CA, USA.
Hyun-Ju LimDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, UCLA Technology Center for Genomics & Bioinformatics, Los Angeles, CA, USA.
Mark I Ii DuhonDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, UCLA Technology Center for Genomics & Bioinformatics, Los Angeles, CA, USA.
Rui LiDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, UCLA Technology Center for Genomics & Bioinformatics, Los Angeles, CA, USA.
Kristina I BoströmDivision of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Xinmin LiDepartment of Pathology & Laboratory Medicine, David Geffen School of Medicine at UCLA, UCLA Technology Center for Genomics & Bioinformatics, Los Angeles, CA, USA.

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Robert Damoiseaux · 1985 to 2026
$134.5M
The Pan-Human Virome Atlas: From Single-Cell Mapping to Population-Scale LandscapesU54AG089335 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JAMES R CERHAN, Yvonne L Kapila · 2025 to 2026
$13.0M
Targeting Super-Enhancers Suppresses Cancer Stemness and Invasion of HNSCCR01DE029173 · NIDCR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WANG, CUN-YU · 2020 to 2024
$2.0M
NCI NIH HHS P30 CA016042NIA NIH HHS U54 AG089335NIDCR NIH HHS R01 DE029173
6 · The paper itself

Abstract

The cellular and molecular mechanisms of acupuncture have been investigated across various tissues in multiple animal models. However, the dynamic cellular and molecular changes at human acupuncture points remain unexplored. The primary challenge preventing such a study is the practical difficulty of obtaining sufficient cells from acupoints. To address this, we developed a new needle manipulation technique that enables the collection of sufficient cell number from the acupuncture needle during the treatment. Using this approach and single-cell technology, we identified eight cell types at the acupoint BL23: inflammatory fibroblast, myofibroblast, skeletal muscle cell, endothelial cell, smooth muscle cell, adipocyte, macrophage, and a novel cell type characterized by marker genes

Indexed as

Acupuncture PointsGene Expression ProfilingSingle-Cell AnalysisTranscriptomeAcupuncture TherapyAdultFemaleHumansMaleacupoint BL23Acupunctureanalgesialow back painsingle cell sequencingsynapse

Identifiers

PMID41312958
PMCPMC12743158

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.