Evidence map›Paper›PMID 41312993›Full record

ArticleAntimicrobial agents and chemotherapy2026

Vitamin C enhances corneal fungal infection treatment in mice via chemotaxis and anti-inflammation.

Yanting Xie, Shoujun Jian, Juan Yue, Chunmei Wang, Junlu Dong, Siyu He, Susu Liu, Liya Wang, Hongmin Zhang

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yanting Xie *Department of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Shoujun Jian *Department of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Juan YueDepartment of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Chunmei WangDepartment of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Junlu DongDepartment of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Siyu HeDepartment of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Susu LiuDepartment of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Liya WangDepartment of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Hongmin ZhangDepartment of Ophthalmology, Henan Key Laboratory of Ophthalmology and Visual Science, Henan Provincial People's Hospital, Henan Eye Hospital, People's Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID 0000-0002-2542-8594

Funding

Guiding Program Project of the Natural Science Foundation of Henan Province 242300420103Henan Eye Hospital Key Program of Basic Research 20JCQN006Henan Eye Hospital Key Program of Basic Research 21JCZD003National Natural Science Foundation of China 81270991National Natural Science Foundation of China 81900835
6 · The paper itself

Abstract

Fungal keratitis (FK) is a persistent and vision-threatening disease. The potential of vitamin C (VC) in tissue protection is well-recognized; however, its specific role in FK and its interaction with antifungal drugs are not well defined. In this study, we investigated the role of VC in FK

Indexed as

Antifungal AgentsAnti-Inflammatory AgentsAscorbic AcidEye Infections, FungalKeratitisAmphotericin BAnimalsApoptosisChemotaxisCorneaDisease Models, AnimalExtracellular TrapsMacrophagesMast CellsMiceMice, Inbred BALB CAmphotericin BAntifungal AgentsAnti-Inflammatory AgentsAscorbic AcidReactive Oxygen Speciesfungal keratitismacrophagemast cellsneutrophil infiltrationvitamin C

Identifiers

PMID41312993
PMCPMC12777558

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.