Evidence map›Paper›PMID 41313018›Full record

Trial reportmSystems2025

Kexin Wang, Hanbo Wang, Zhixin Zhao, Xin Shen, Jianmin Zhao, Heping Zhang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kexin Wang *Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.ORCID 0009-0005-9008-7756
Hanbo Wang *The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.ORCID 0009-0004-9678-4176
Zhixin ZhaoInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Xin ShenInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.
Jianmin ZhaoDepartment of Orthopaedics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.ORCID 0000-0002-4201-2638
Heping ZhangInner Mongolia Key Laboratory of Dairy Biotechnology and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China.ORCID 0000-0002-4140-7486

Funding

Fundamental Research Funds of Inner Mongolia Agricultural University BR221203National Key Research and Development Program of China 2022YFD2100700National Natural Science Foundation of China U22A20540
6 · The paper itself

Abstract

Knee osteoarthritis (KOA) is a chronic joint disease marked by cartilage degradation and inflammation. Probiotics exhibit anti-inflammatory properties and may influence the gut-joint axis. Thus, a 4-month human trial was conducted to assess the adjunctive effects of IMPORTANCE: The pathogenesis of knee osteoarthritis (KOA) and its phenotypic expression have been associated with the human gut microbiota. Our study demonstrated that the co-administration of Probio-M8 with chondroitin sulfate significantly alleviates KOA symptoms. This probiotic intervention enhances therapeutic efficacy through modulation of the gut microbiota and associated metabolic pathways, reducing inflammation and improving clinical outcomes. Our results underscore the potential of probiotic-driven therapies as an adjunctive treatment strategy and underscore the importance of the gut-joint axis in KOA management.

Indexed as

Bifidobacterium animalisChondroitinChondroitin SulfatesGastrointestinal MicrobiomeOsteoarthritis, KneePostmenopauseProbioticsAgedFemaleHumansMiddle AgedTreatment OutcomeChondroitinChondroitin SulfatesBifidobacterium animalis subsp. lactis Probio-M8gut metabolomegut microbiomeknee osteoarthritisprobiotic adjuvant therapy

Identifiers

PMID41313018
PMCPMC12710372

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.