Evidence mapPaperPMID 41313194Full record

ReviewArchives of endocrinology and metabolism2025

Autonomic neuropathy in diabetes.

Lucianne Righeti Monteiro Tannus, Roberta Arnoldi Cobas

Abstract readReview
In one paragraph

Review in Archives of endocrinology and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Lucianne Righeti Monteiro TannusDepartamento de Clínica Médica, Unidade de Diabetes, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.ORCID 0000-0001-6598-1346
Roberta Arnoldi CobasDepartamento de Clínica Médica, Unidade de Diabetes, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.ORCID 0000-0002-5062-0182

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic autonomic neuropathy (DAN) is a serious and often under-recognized complication of diabetes that can affect any division of the autonomic nervous system (ANS), presenting with a wide range of signs and symptoms. The pathophysiology of DAN involves a complex interplay of hyperglycemia-driven metabolic and vascular pathways, oxidative stress, inflammation, and autonomic imbalance, ultimately leading to progressive nerve dysfunction. Cardiovascular autonomic neuropathy (CAN) has emerged as a particularly severe condition, associated with heightened risk of arrhythmia, silent myocardial ischemia, heart failure, and mortality. DAN, however, extends beyond the cardiovascular system, encompassing gastrointestinal (GI), genitourinary (GU), and sudomotor dysfunctions, that strongly impair quality of life. Despite its impact, DAN remains largely overlooked in clinical practice due to its subclinical onset, non-specific symptoms, and limited routine screening. This review integrates basic, epidemiological, and clinical data to provide a practical understanding of DAN with the aim of helping clinicians to suspect, investigate and manage DAN, with particular attention to its cardiovascular (CV), GI, and GU manifestations.

Indexed as

Autonomic Nervous System DiseasesDiabetic NeuropathiesAutonomic Nervous SystemCardiovascular DiseasesHumansQuality of Lifecardiovascular autonomic neuropathydiabetes mellitusdiabetic autonomic neuropathyDiabetic neuropathyheart rate variability

Identifiers

PMID41313194
PMCPMC12671339

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.