ArticleJournal of magnetic resonance imaging : JMRI2026
Prospective Comparison of DWI-Derived Virtual MR Elastography and Conventional MR Elastography in Metabolic Dysfunction-Associated Steatotic Liver Disease and Healthy Volunteers.
Article in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundVirtual MR elastography (VMRE) and MRE have been proposed for liver fibrosis staging in metabolic dysfunction-associated steatotic liver disease (MASLD), but VMRE's diagnostic performance remains debated. PURPOSE: To assess the inter-visit and inter-reader reproducibility of fat-uncorrected and fat-corrected diffusion-weighted imaging (DWI)-based VMRE and to compare their diagnostic performance with MRE for liver fibrosis staging in the MASLD population. STUDY TYPE: Prospective. POPULATION: Fifty four participants were enrolled: 43 with biopsy-proven MASLD (age: 57.0 ± 9.0 years; 26 males) and 11 healthy volunteers (age: 31.0 ± 15.0 years; 4 males). FIELD STRENGTH/SEQUENCE: 3.0T, DWI (b-values of 0, 200, and 1500 s/mm ASSESSMENT: VMRE-derived shifted apparent diffusion coefficients (sADC) reproducibility and diagnostic performance; MRE-derived stiffness diagnostic performance. STATISTICAL TESTS: Reproducibility was evaluated using intraclass correlation coefficients (ICC), within-subject coefficient of variation (wCV), and bias and limits of agreement (LOA) in Bland-Altman analysis. Diagnostic performance was assessed with areas under the receiver operating characteristic curve (AUC) and compared with DeLong's test. p < 0.05 was considered statistically significant.
resultsFor inter-visit agreement, the ICC of fat-uncorrected and fat-corrected sADC were 0.88 and 0.83; wCV were 0.120 ± 0.30 and 0.141 ± 0.31; bias and 95% LOA were (-0.03 ± 0.18) × 10 DATA
conclusionVMRE has good reproducibility, but has lower fibrosis staging accuracy than MRE. EVIDENCE LEVEL: 1. TECHNICAL EFFICACY: Stage 2.
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