ArticleDiscover oncology2025
MiR-205-5p downregulation and circ_100290 upregulation in glioblastoma patients are associated with tumor aggressiveness.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
backgroundGlioblastoma multiforme (GBM), the most prevalent and challenging-to-diagnose brain tumor, is a highly lethal and largely untreatable form of brain cancer. Circular RNAs (CircRNAs) and microRNAs (miRNAs) may serve as biomarkers for GBM diagnosis and treatment. Circ_100290 and miR-205-5p play a key role in gene regulation, tumor progression, and cellular communication, making them valuable biomarkers for GBM, but their precise role in GBM remains unclear and requires further investigation.
methodsBioinformatics analyses were conducted to explore interactions between miR-205-5p and circ_100290, their functional roles, and associated pathways. Additionally, we assessed the differences of miR-205-5p and circ_100290 between tumor and normal samples by analyzing the quantitative real-time PCR.
resultsBioinformatics analysis revealed a network association of miR-205-5p and circ_100290 to key proteins (PTEN, SMAD4, CDK19, ELAVL1, HNRNPK, DDX5, AGO2, and EIF4A3) and pathways, including Wnt signaling, highlighting their roles in splicing and gene expression regulation and the regulation of tumor development and metastasis. QRT-PCR analysis revealed a significant downregulation of miR-205-5p and an upregulation of circ_100290 compared to normal tissues. Notably, the downregulation of miR-205-5p was associated with increased tumor volume and lobar tumor localization, whereas the upregulation ofcirc_100290 correlated with IDH1 gene mutations in GBM patients.
conclusionsOur study highlights miR-205-5p downregulation and circ_100290 upregulation in GBM patients which underscore their diagnostic potential and cooperative role in GBM progression, offering novel insights for therapeutic targeting.
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