Evidence mapPaperPMID 41313467Full record

ArticleEuropean journal of ophthalmology2026

Relationship between monocyte-to-lymphocyte ratio and age-related macular degeneration: Findings from a national cross-sectional study.

Xinyi Cheng, Tibor Lohmann, Sandra Johnen, Peter Walter, Sabine Baumgarten

Abstract readMulticenter Study
In one paragraph

Article in European journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xinyi ChengDepartment of Ophthalmology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0001-6402-1263
Tibor LohmannDepartment of Ophthalmology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0003-4432-1853
Sandra JohnenDepartment of Ophthalmology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0003-0028-2557
Peter WalterDepartment of Ophthalmology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0001-8745-6593
Sabine BaumgartenDepartment of Ophthalmology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0001-5784-4050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundRecent advances have revealed the important role of the immune system in the progression of age-related macular degeneration (AMD). Monocyte-to-lymphocyte ratio (MLR) is a combined marker reflecting inflammation status. However, research on the correlation between MLR and AMD is limited.MethodsIn this cross-sectional analysis, weighted multivariable logistic regression, multinomial logistic regression, subgroup analysis, smoothed curve fitting and threshold effect analysis were used to investigate the relationship between MLR and AMD based on data from the 2005-2008 National Health and Nutrition Examination Survey (NHANES).ResultsThis study included data of 4,655 participants. The proportions of no AMD, early AMD and late AMD were 92.27%, 6.79% and 0.95%, respectively. After adjusting for covariates, weighted multivariable logistic regression analysis revealed that MLR was positively associated with AMD (

Indexed as

LymphocytesMacular DegenerationMonocytesAgedCross-Sectional StudiesFemaleHumansLymphocyte CountMaleMiddle AgedNutrition SurveysPrevalenceROC CurveUnited StatesAMDinflammationMLRNHANES

Identifiers

PMID41313467
PMCPMC13091922

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.