Evidence map›Paper›PMID 41313470›Full record

ArticleEuropean radiology2026

Association between MR neurography-based objective quantitative parameters in inferior alveolar nerve and lingual nerve injuries.

Mengjie Zhang, Ce Zhu, Hongrong Sun, Yabing Dong, Liang Huo, Yiwen Wang, Ying Chai, Wenhao Zhang, Yuemin Liu, Zixiang Han and 4 more

Abstract read
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In one paragraph

Article in European radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Mengjie Zhang *Department of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ce Zhu *National Center for Stomatology, and National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
Hongrong Sun *Research Center for Lifespan Health, Wuhan University, Wuhan, China.
Yabing DongDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liang HuoDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yiwen WangDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ying ChaiDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wenhao ZhangDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuemin LiuDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zixiang HanDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi SunDepartment of Radiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Minjun DongDepartment of Radiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. peter_dongmj@yeah.net.
Wenbin WeiDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. tian_qian_cool@126.com.
Minjie ChenDepartment of Oral Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. chenmj_9hospital@126.com.ORCID http://orcid.org/0000-0001-7087-4430

Funding

National Natural Science Foundation of China 82370981National Natural Science Foundation of China 82401149Rare disease registration project of Shanghai Ninth People's Hospital JYHJB202204The Key Research and Development Program of Hubei Province CZKYXM2023036JZ
6 · The paper itself

Abstract

objectivesThe diagnosis of inferior alveolar nerve (IAN) and lingual nerve (LN) injuries currently relies on imaging and clinical examinations. Magnetic resonance neurography (MRN) demonstrates limited sensitivity in mild-to-moderate IAN and LN injuries, while quantifiable parameters correlating with symptomatology and prognostic outcomes remain undefined. MATERIALS AND

methodsThis study retrospectively reviewed 24 patients with IAN or LN injuries. Their clinical and imaging data were collected. MRN-based parameters, including apparent signal-to-noise ratio (aSNR) and apparent nerve-muscle contrast-to-noise ratio (aNMCNR), were calculated.

resultsAmong the 24 patients, there were 17 patients with IAN injuries and 7 with LN injuries. This investigation demonstrated significantly elevated aSNR and aNMCNR on the injured side of mild-to-moderate IAN/LN injuries compared to healthy nerves (all p < 0.05). The injury-to-healthy ratios (aSNRi/h, aNMCNRi/h) exhibited marked increases relative to the internal control group (all p < 0.05). aNMCNRi/h showed inverse correlations with visual analog scale (VAS) scores and 5 Hz current perception threshold (CPT) measurements (p = 0.041 and p = 0.048, respectively). Longitudinal analysis in the 1-year follow-up cohort (n = 15) revealed a positive linear relationship between aNMCNRi/h and subsequent prognostic improvement magnitude (p < 0.001).

conclusionsThis investigation establishes, for the first time, the clinical validity of aNMCNRi/h as a quantitative imaging parameter correlating with symptom severity and prognostic trajectories in mild-to-moderate IAN/LN injuries. The proposed parameter demonstrates potential for guiding patient-specific clinical decision-making, with implications for standardizing diagnostic protocols and optimizing rehabilitation strategies. KEY POINTS: Question Objective quantitative parameters correlating with symptomatology and prognosis in mild-to-moderate Inferior alveolar nerve (IAN) and lingual nerve (LN) injuries remain unestablished. Findings The apparent nerve-muscle contrast-to-noise ratio injured-to-healthy ratio demonstrates correlation with both symptomatology and prognostic outcomes in mild-to-moderate IAN and LN injuries. Clinical relevance This study pioneers the proposal of magnetic resonance neurography-based quantitative parameters correlating with symptomatology and prognosis, thereby addressing critical limitations of conventional Sunderland grading in the diagnostic-therapeutic management of mild-to-moderate IAN and LN injuries.

Indexed as

Lingual Nerve InjuriesMagnetic Resonance ImagingMandibular NerveMandibular Nerve InjuriesAdolescentAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesSensitivity and SpecificitySignal-To-Noise RatioYoung AdultInferior alveolar nerveLingual nerve injuriesMagnetic resonance neurographyPrognosis

Identifiers

PMID41313470

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.