Evidence map›Paper›PMID 41313488›Full record

ArticleArchives of virology2025

Permissive infection of murine osteoblastic MC3T3-E1 cells by goatpox virus: establishing a novel cell model for mechanistic studies of host-pathogen interactions.

Huibao Wang, Lina Tong, Hongqiang Zhang, Fangping Wang, Haotai Chen, Shanhui Ren, Xiaolong Gao

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Huibao Wang *School of Environment Engineering, Gansu Forestry Voctech University, Tianshui, 741020, P.R. China.
Lina Tong *College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, P.R. China.
Hongqiang ZhangState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, P.R. China.
Fangping WangDingxi Vocational and Technical College, Dingxi, Gansu, 730500, P.R. China.
Haotai ChenState Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, P.R. China.
Shanhui Ren *State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046, P.R. China. renshanhui@caas.cn.ORCID http://orcid.org/0000-0002-3065-2355
Xiaolong Gao *College of Agriculture and Animal Husbandry, Qinghai University, Xining, Qinghai, 810016, P.R. China. gaoxiaolong1017@163.com.

Funding

Innovative Research Group Project of the National Natural Science Foundation of China 32302850Innovative Research Group Project of the National Natural Science Foundation of China 32460876Qinghai Provincial Department of Science and Technology 2024-ZJ-721
6 · The paper itself

Abstract

Goatpox is a highly contagious viral disease that poses a significant threat to the health of goats and other small ruminants. Here, we report for the first time that the murine osteoblastic cell line MC3T3-E1 supports productive GTPV infection, as demonstrated by Western blotting, indirect immunofluorescence assay, and flow cytometry. RNA sequencing revealed thousands of differentially expressed genes (DEGs). Signaling pathways and functions of the DEGs were analyzed using Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. Real-time quantitative PCR further confirmed the expression of several DEGs. The present study extends the host range for GTPV replication and mechanistic investigations.

Indexed as

CapripoxvirusHost-Pathogen InteractionsOsteoblastsAnimalsCell LineGoatsMiceVirus Replication

Identifiers

PMID41313488

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.