ArticleDiscover oncology2025
PTBP1 functions as a suppressor of ferroptosis in endometrial carcinoma cells by stabilizing SLC7A11 mRNA.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- RSPO2-induced ferroptosis via PTBP1-mediated FSP1 mRNA decay suppresses breast cancer progression.Frontiers in oncology · 2026Article
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8 authors.
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Abstract
The RNA-binding protein polypyrimidine tract-binding protein 1 (PTBP1) facilitates tumor progression in various cancers by interacting with mRNAs of key oncogenes and tumor suppressors, thereby regulating their mRNA stability, alternative splicing, and protein translation. In this study, we found that PTBP1 knockdown notably inhibited both in vitro cell viability and in vivo tumor growth in endometrial cancer (EC) cells. Elevated PTBP1 protein levels were also observed in endometrial cancer tissues compared to normal endometrial tissues. Transcriptomic sequencing revealed that PTBP1 depletion might impact lipid metabolism and ferroptosis in endometrial cancer cells. Through measurements of intracellular reactive oxygen species (ROS), glutathione (GSH), malondialdehyde (MDA), and Fe
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