Evidence map›Paper›PMID 41313583›Full record

Observational studyJournal of magnetic resonance imaging : JMRI2026

Contrast-Enhanced MR Fingerprinting With Delta-Relaxometry: Investigating a New Avenue for Tumor Characterization.

Shengwen Deng, Walter Zhao, Sree Gongala, Jessie E P Sun, David W Jordan, Chris A Flask, Mark A Griswold, Dan Ma, Chaitra Badve

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of magnetic resonance imaging : JMRI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shengwen DengDepartment of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Walter ZhaoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.ORCID https://orcid.org/0000-0001-8907-4935
Sree GongalaDepartment of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Jessie E P SunDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA.
David W JordanDepartment of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Chris A FlaskDepartment of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Mark A GriswoldDepartment of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
Dan MaDepartment of Neurosurgery, Duke University, Durham, North Carolina, USA.
Chaitra BadveDepartment of Radiology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
MR Fingerprinting based Quantitative Imaging and Analysis Platform (MRF-QIA) for brain tumors.R01CA269604 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI BADVE, CHAITRA, DAVATZIKOS, CHRISTOS · 2023 to 2025
$1.7M
American Cancer Society Institutional Research GrantClinical and Translational Science Award (CTSA) UL1TR002548Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve UniversityNational Center for Advancing Translational Science (NCATS)NCATS NIH HHS UL1 TR002548NCI NIH HHS R01 CA269604NIH HHS R01 CA269604Radiation Oncology InstituteSiemens HealthineersThe Imaging Devices and AI Technologies Track Funding Agency (Jobs Ohio)
6 · The paper itself

Abstract

backgroundMRI contrast agents enhance lesion characterization by altering tissue relaxation properties. However, quantitative assessment of contrast enhancement is limited by variability in contrast administration parameters, and lack of efficient and precise contrast concentration independent relaxivity (r PURPOSE: To introduce an MRF-derived delta-relaxometry method for mapping contrast-specific relaxivity ratios (r STUDY TYPE: Prospective, observational. POPULATION: Phantom studies and 29 patients (15 glioblastoma, 14 brain metastases). FIELD STRENGTH/SEQUENCE: 3 T; pre- and post-contrast 3D whole-brain MR Fingerprinting. ASSESSMENT: Mathematical derivations established a relationship between ΔR STATISTICAL TEST: Coefficient of variation; coefficient of determination; Mann-Whitney U tests with Benjamini-Hochberg correction.

resultsΔR EVIDENCE LEVEL: 3 (retrospective cohort study with imperfectly applied reference standard). TECHNOLOGY EFFICACY: 1 (feasibility study with quantitative assessment, requires a comparison with standard of care).

Indexed as

Brain NeoplasmsContrast MediaGlioblastomaMagnetic Resonance ImagingAdultAgedAlgorithmsBrainFemaleHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedPhantoms, ImagingProspective StudiesContrast Mediabrain metastasescontrast‐enhanced MRIdelta‐relaxometryglioblastomaMR fingerprinting (MRF)relaxivity

Identifiers

PMID41313583
PMCPMC12963811

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.