Evidence map›Paper›PMID 41313694›Full record

ArticleThe Kaohsiung journal of medical sciences2026

Forsythiaside A Alleviates Kidney Injury and Intestinal Epithelium Dysfunction in IgA Nephropathy by Inhibiting TLR4/NF-κB Signaling.

Meng-Si Li, Kai Liu

Abstract read
In one paragraph

Article in The Kaohsiung journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Meng-Si LiDepartment of Nephrology, China Resources & WISCO General Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China.
Kai LiuDepartment of Nephrology, China Resources & WISCO General Hospital, Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China.ORCID https://orcid.org/0009-0003-3241-4128

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgA nephropathy (IgAN), the most common form of glomerulonephritis, is a major and growing public health issue. It results from intestinal barrier dysfunction that leads to mesangial deposition of pathogenic galactose-deficient IgA1 (Gd-IgA1) and renal inflammation. This study aimed to investigate the therapeutic effects and associated mechanisms of forsythiaside A on intestinal barrier injury in IgAN in animal models. Rats were treated with bovine serum albumin (BSA), carbon tetrachloride (CCl

Indexed as

Glomerulonephritis, IGAGlycosidesIntestinal MucosaKidneyNF-kappa BToll-Like Receptor 4AnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticBlood Urea NitrogenCD68 MoleculeCreatinineDisease Models, AnimalInterleukin-6Intestinal Barrier FunctionLipopolysaccharidesAntigens, CDAntigens, Differentiation, MyelomonocyticCD68 MoleculeCD68 protein, ratCreatinineforsythiasideGlycosidesIl6 protein, ratInterleukin-6LipopolysaccharidesNF-kappa BRela protein, ratTlr4 protein, ratToll-Like Receptor 4Transcription Factor RelATumor Necrosis Factor-alphaforsythiaside AIgA nephropathyinflammationintestinal barrier injuryTLR4/NF‐κB pathway

Identifiers

PMID41313694
PMCPMC13248804

What Socratic holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.