Evidence map›Paper›PMID 41313750›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Label-Free Leukocyte Biophysical Profiling Using Impedance-Deformability Cytometry for Rapid Cardiovascular Risk Stratification.

Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J Chung, Nguan Soon Tan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Linwei HeSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.ORCID https://orcid.org/0009-0003-5708-6204
Hui Min TaySchool of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.ORCID https://orcid.org/0000-0002-4981-5994
Feng ChenLee Kong Chian School of Medicine, Nanyang Technological University, Mandalay Rd, Singapore, 308232, Singapore.ORCID https://orcid.org/0009-0002-8134-1204
Hong Sheng ChengLee Kong Chian School of Medicine, Nanyang Technological University, Mandalay Rd, Singapore, 308232, Singapore.ORCID https://orcid.org/0000-0001-9745-7872
Liang De WangLee Kong Chian School of Medicine, Nanyang Technological University, Mandalay Rd, Singapore, 308232, Singapore.ORCID https://orcid.org/0000-0002-0408-2010
Qiqi NamLee Kong Chian School of Medicine, Nanyang Technological University, Mandalay Rd, Singapore, 308232, Singapore.ORCID https://orcid.org/0009-0004-0311-6639
Arunachalam ThannirmalaiSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Lingyan GongSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.ORCID https://orcid.org/0009-0007-6974-9609
Aram J ChungSchool of Biomedical Engineering, Korea University, 145 Anam-ro, Seongbuk District, Seoul, 02841, Republic of Korea.ORCID https://orcid.org/0000-0003-4984-0222
Nguan Soon TanLee Kong Chian School of Medicine, Nanyang Technological University, Mandalay Rd, Singapore, 308232, Singapore.ORCID https://orcid.org/0000-0003-0136-7341
King Ho Holden LiSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.ORCID https://orcid.org/0000-0001-6187-6434
Rinkoo DalanEndocrinology Department, Tan Tock Seng Hospital, 11 Jln Tan Tock Seng, Singapore, 308433, Singapore.ORCID https://orcid.org/0000-0001-9769-2696
Siu Ling WongLee Kong Chian School of Medicine, Nanyang Technological University, Mandalay Rd, Singapore, 308232, Singapore.ORCID https://orcid.org/0000-0002-2294-3187
Han Wei HouSchool of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.ORCID https://orcid.org/0000-0001-6631-6321

Funding

Lee Kong Chian School of Medicine Vascular Research Initiative 022415-00001Nanyang Technological University LKCMedicine (Dean's Postdoctoral Fellowship)Nanyang Technological University (Nanyang Presidents' Graduate Scholarship (NPGS))National Research Foundation Singapore Competitive Research Program NRF CRP25-2020RS-0001Singapore Ministry of Education (MOE) Academic Research Fund Tier 2 MOE-T2EP30120-0004
6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) presents a global health burden with cardiovascular disease (CVD) as its leading cause of mortality. A rapid clinical-adaptable microfluidic workflow for label-free CVD risk profiling based on neutrophil biophysical abnormalities is developed. This high-throughput single cell (>1,000 cells min

Indexed as

Cardiovascular DiseasesDiabetes Mellitus, Type 2LeukocytesAnimalsElectric ImpedanceFemaleHumansMaleMiceMiddle AgedNeutrophilsRisk Assessmentbiophysical profilingdiabetesimpedance cytometrymicrofluidicstranslational diagnostics

Identifiers

PMID41313750
PMCPMC12904061

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.