Evidence map›Paper›PMID 41314410›Full record

ReviewSeminars in neurology2026

Review of Artificial Intelligence for Clinical Use in Alzheimer's Disease and Related Dementias.

Andrew G Breithaupt, Alice Tang, Emily W Paolillo, Merna Bibars, Erik C B Johnson, Rowan Saloner, Katherine L Possin, Charles C Windon, Tanisha G Hill-Jarrett, Joseph Giorgio and 4 more

Abstract readReview
In one paragraph

Review in Seminars in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andrew G BreithauptDepartment of Neurology, Emory University School of Medicine, Emory Goizueta Brain Health Institute, Atlanta, Georgia, United States.
Alice TangBakar Computational Health Sciences Institute and School of Medicine, University of California, San Francisco, San Francisco, California, United States.
Emily W PaolilloDepartment of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States.
Merna BibarsWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.
Erik C B JohnsonDepartment of Neurology, Emory University School of Medicine, Emory Goizueta Brain Health Institute, Atlanta, Georgia, United States.
Rowan SalonerDepartment of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States.
Katherine L PossinDepartment of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States.
Charles C WindonDepartment of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States.
Tanisha G Hill-JarrettDepartment of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States.
Joseph GiorgioDepartment of Neuroscience, University of California, Berkeley, Berkeley, California, United States.
Andreas M RauscheckerDepartment of Radiology and Biomedical Imaging, Center for Intelligent Imaging, University of California, San Francisco, San Francisco, California, United States.
Hyeokhyen KwonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, United States.
Jet M J VonkDepartment of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States.
Pedro Pinheiro-ChagasDepartment of Neurology, Memory and Aging Center, Weill Institute for Neuroscience, University of California, San Francisco, California, United States.

Funding

The Care Ecosystem Response to COVID-19: Accelerating Research on Dementia Care that Meets the Needs of Caregivers and Persons with Dementia during COVID-19R01AG074710 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL · 2022 to 2024
$9.1M
Augmenting Nurse Support and EHR Integration for the Pragmatic Trial of the UCSF-BHAU01NS128913 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine Laurel Possin · 2022 to 2026
$8.2M
Reimagining Precision Medicine Approaches to AD DiagnosisR35AG072362 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI POSSIN, KATHERINE LAUREL, RABINOVICI, GIL DAN · 2021 to 2025
$4.8M
Structural Gendered RacismK23AG084871 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Tanisha G Hill-Jarrett · 2024 to 2026
$593k
Passive digital phenotyping for capturing real-world neurobehavior in neurodegenerative diseaseK23AG084883 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emily Paolillo · 2024 to 2026
$592k
National Institute on Aging of the National Institutes of Health K23AG093166NIA NIH HHS K23 AG084871NIA NIH HHS K23 AG084883NIA NIH HHS R01 AG074710NIA NIH HHS R35 AG072362NINDS NIH HHS U01 NS128913
6 · The paper itself

Abstract

As the U.S. population ages, Alzheimer's disease and related dementias (ADRD) cases are increasing, resulting in long wait times for specialist care. We review state-of-the-art artificial intelligence (AI) applications in ADRD care, from streamlining clinical diagnosis to pioneering novel digital biomarkers. Near-term AI applications include neuroimaging interpretation, conversational agents for patient interviews, and digital cognitive assessments. Large language models show promise as collaborative partners, helping clinicians interpret complex data while supporting patients and caregivers. Emerging digital biomarkers-speech analysis, passive monitoring through wearable devices, electronic health record analysis, and multiomics-offer potential for continuous monitoring to detect cognitive decline years before traditional assessments. Despite the acceleration of AI innovation, most of these systems are inaccessible in clinical practice. Implementation bottlenecks include limited external validation, technical challenges, model biases, infrastructure, and regulatory requirements. This review aims to help neurologists navigate this rapidly evolving AI landscape and prepare for implementation in ADRD care.

Indexed as

Alzheimer DiseaseArtificial IntelligenceDementiaHumansNeuroimaging

Identifiers

PMID41314410
PMCPMC13078895

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.