Evidence map›Paper›PMID 41314685›Full record

ArticleOpen heart2025

Analysis of left ventricular mass for African American individuals using multi-ancestry polygenic risk scores: the Jackson Heart Study.

Douglas McLaurin, Philip Turk, Olivia Affuso, Laura M Raffield, Elizabeth Heitman

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Open heart, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Douglas McLaurinThe University of Mississippi Medical Center, Jackson, Mississippi, USA dmclaurin@umc.edu.ORCID http://orcid.org/0000-0003-4113-3419
Philip TurkNortheast Ohio Medical University, Rootstown, Ohio, USA.
Olivia AffusoCouncil on Black Health, Knightdale, North Carolina, USA.
Laura M RaffieldDepartment of Genetics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Elizabeth HeitmanThe University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Funding

Hypertension and Cardiorenal Research Training ProgramT32HL105324 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Joey P. Granger · 2010 to 2026
$7.8M
NHLBI NIH HHS HHSN268201800010INHLBI NIH HHS HHSN268201800011CNHLBI NIH HHS HHSN268201800011INHLBI NIH HHS HHSN268201800012CNHLBI NIH HHS HHSN268201800012INHLBI NIH HHS HHSN268201800014CNHLBI NIH HHS HHSN268201800014INHLBI NIH HHS HHSN268201800015INHLBI NIH HHS T32 HL105324NIMHD NIH HHS HHSN268201800013I
6 · The paper itself

Abstract

backgroundLeft ventricular mass (LVM) is suggested to be a sensitive predictor of adverse cardiovascular outcomes, such as heart failure. In recent years, genome-wide association studies have discovered loci that associate with outcomes related to LVM, providing an opportunity for the development of genetic risk scores. However, the relevance of these genetic variants to non-European ancestry groups requires additional testing. Here, we examined if variants that have been associated with heart failure and LVM in multi-ancestry populations are associated with LVM among African American individuals in the Jackson Heart Study (JHS).

methodsHeart failure and LVM associated variants were identified from two published multi-ancestry studies. Two polygenic risk scores (PRSs) were computed for 2175 African American participants (mean age 53, 63% female). We assessed the linear association of both PRSs with LVM indexed to height (LVM

resultsLinear correlation analysis showed positive associations between age and LVM

conclusionWe find insufficient evidence to suggest that heart failure and LVM genetic variants derived from predominantly European multi-ancestry populations are linearly associated with log LVM among African American participants in the JHS.

Indexed as

Black or African AmericanHeart FailureHeart VentriclesHypertrophy, Left VentricularMultifactorial InheritanceAdultAgedFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreGenome-Wide Association StudyHumansMaleMiddle AgedMississippiPhenotypeEpidemiologyGenetic Association StudiesHeart FailureRisk Factors

Identifiers

PMID41314685
PMCPMC12666220

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.