Evidence map›Paper›PMID 41315048›Full record

ArticleContact dermatitis2026

Results of GC-MS Analyses of 40 Extracts of Diabetes Devices.

Emma M van Oers, Anton C de Groot, Patrick Verolme, Norbertus A Ipenburg, Thomas Rustemeyer

Abstract read
In one paragraph

Article in Contact dermatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Emma M van OersAmsterdam University Medical Centers, Amsterdam, the Netherlands.
Anton C de GrootDermato-Allergology and Occupational Dermatology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0002-6666-7292
Patrick VerolmeNEDLAB, Middelharnis, the Netherlands.
Norbertus A IpenburgDermato-Allergology and Occupational Dermatology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0003-0679-4131
Thomas RustemeyerDermato-Allergology and Occupational Dermatology, Amsterdam University Medical Centers, Amsterdam, the Netherlands.ORCID https://orcid.org/0000-0001-7580-0684

Funding

Dutch Diabetes Research Foundation 2024.30.002
6 · The paper itself

Abstract

backgroundDiagnostic patch testing in patients with suspected allergic Contact Dermatitis from glucose sensors, insulin pumps, and infusion sets is seriously hampered by a lack of information on the chemical composition of these diabetes devices.

objectivesTo identify the chemicals present in diabetes devices. MATERIALS AND

methodsForty acetone extracts of 27 devices (10 sensors, 3 patch pumps, 12 infusion sets and 2 single adhesives) were investigated by gas chromatography-mass spectrometry.

resultsTwo hundred eighty four individual chemicals were identified. All 40 extracts contained one or more chemicals that were previously identified as allergens in diabetes devices causing allergic Contact Dermatitis. Fourteen of 27 devices (52%) contained one or more acrylates, 8 (30%) colophonium derivatives, all 27 (100%) one or two phenolic allergens (2,4-di-tert-butylphenol, p-tert-butylphenol, butylated hydroxytoluene), and 9 (33%) 1-hydroxycyclohexyl phenyl ketone. None of the other chemicals were well-known haptens, with the exception of bisphenol A, which was present in half of the extracts, in some cases in very high concentrations.

conclusionsAll products investigated contained chemicals already known to be sensitizers in diabetes devices. The data can help determine the relevance of positive patch tests, facilitate targeted patch testing with potential allergens and aid in advising safer alternatives for sensitized patients.

Indexed as

AllergensDermatitis, Allergic ContactInsulin Infusion SystemsAcrylatesAdhesivesBlood Glucose Self-MonitoringGas Chromatography-Mass SpectrometryHumansPatch TestsPhenolsAcrylatesAdhesivesAllergensPhenolsacrylatesallergenscolophoniumdiabetes devicesgas chromatography—mass spectrometryGC–MSglucose sensorinsulin pumpisocyanatesphenolic chemicals

Identifiers

PMID41315048
PMCPMC12872336

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.