Role of vitamin C infusion in postoperative mechanically ventilated neonates with sepsis: a randomized controlled trial.

This research investigated the efficacy of intravenous vitamin C administration in septic, mechanically ventilated (MV) full-term neonates following surgical interventions. This double-blinded randomized controlled trial included 50 full-term neonates who required mechanical ventilation and developed confirmed sepsis after surgery. Neonates were randomly assigned to receive either standard sepsis management with placebo (No Vitamin C group) or standard protocol with vitamin C infusion, administered as a 0.5 g/kg loading dose followed by a maintenance dose of 0.5 g/kg/h over 6 h, continued for 7 to 10 days (Vitamin C group). Respiratory rate and peak inspiratory pressure were significantly lower at 24 h, 72 h, and 120 h in the Vitamin C group than in the No Vitamin C group. FiO₂ requirements were significantly reduced at 72 h and 120 h in the Vitamin C group. SpO

conclusionVitamin C infusion significantly improved respiratory parameters and reduced the duration of MV and inotropic support requirements in septic neonates following surgery, though it did not significantly affect the NICU or hospital length of stay or mortality.

trial registrationregistered on ClinicalTrials.gov (ID: NCT06780345) (date: 17/1/2025). WHAT IS KNOWN: • In neonatal intensive care units (NICU), neonatal sepsis continues to be a major cause of death and morbidity. • Vitamin C has become a possible therapeutic intervention given its many pathways in sepsis control. WHAT IS NEW: • Vitamin C infusion significantly improved respiratory parameters and reduced the duration of MV and inotropic support requirements in septic neonates following surgery, though it did not significantly affect the NICU or hospital length of stay or mortality.