Evidence map›Paper›PMID 41315130›Full record

ReviewMolecular neurobiology2025

Membrane Trafficking in Psychiatric Disorders: Bridging Cellular Dysfunction and Mental Health-A Narrative Review.

Maiara de Aguiar da Costa, Lucas Cândido Pedro, Maria Fernanda Pedro Ebs, Henrique Medeiros Menegaz, Sofia Januário Bolan, Amanda Duarte Machado, Júlio César Claudino Dos Santos, Gislaine Zilli Réus, Cinara Ludvig Gonçalves

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Maiara de Aguiar da CostaLaboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil.ORCID http://orcid.org/0000-0001-6500-4908
Lucas Cândido PedroLaboratory of Translational Psychiatry, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil.ORCID http://orcid.org/0000-0001-6608-7215
Maria Fernanda Pedro EbsLaboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil.ORCID http://orcid.org/0009-0008-0352-9483
Henrique Medeiros MenegazLaboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil.
Sofia Januário BolanLaboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil.ORCID http://orcid.org/0000-0002-2666-3270
Amanda Duarte MachadoLaboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil.
Júlio César Claudino Dos SantosLaboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil.ORCID http://orcid.org/0000-0001-6543-481X
Gislaine Zilli RéusLaboratory of Translational Psychiatry, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil.ORCID http://orcid.org/0000-0001-6073-0855
Cinara Ludvig GonçalvesLaboratory of Experimental Neurology, Graduate Program in Health Sciences, University of Southern of Santa Catarina (UNESC), Criciúma, SC, Brazil. cinaralg@unesc.net.ORCID http://orcid.org/0000-0003-2468-8885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Membrane trafficking is a fundamental cellular process responsible for transporting proteins and lipids within and between cells, essential for maintaining cellular homeostasis and supporting proper neuronal function. This narrative review examines the role of membrane trafficking in psychiatric disorders, focusing on autism spectrum disorder (ASD) and major depressive disorder (MDD), and discusses its potential as a target for pharmacological interventions. Emerging evidence shows that dysregulation of membrane trafficking is implicated in these conditions. In neurons, this process is central to synaptic transmission, neurotransmitter release, and receptor recycling, supporting neurodevelopment and brain plasticity. Disruptions can lead to altered synaptic connectivity, impaired neuroplasticity, and reduced responsiveness to pharmacological treatments. Recent studies also highlight the involvement of endosomal trafficking pathways, cytoskeletal proteins, and mitochondrial transport in their pathophysiology. Understanding the molecular mechanisms that regulate membrane trafficking may provide new insights into the etiology of ASD and MDD and open avenues for novel therapeutic strategies aimed at improving intracellular communication and neuroplasticity.

Indexed as

Cell MembraneMental DisordersMental HealthAnimalsHumansNeuronal PlasticityProtein TransportAutism spectrum disorderMajor depressive disorderMembrane traffickingNeurotransmissionPsychiatric disordersSynaptic plasticity

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.