Evidence map›Paper›PMID 41315267›Full record

ArticleNature communications2025

NEK7 couples SDHB to orchestrate respiratory chain electron transport homeostasis that impedes liver fibrosis.

Zhenzhen Sun, Le Sun, Hu Hua, Ying Ren, Wenping Zhu, Xu Wang, Wei Gu, Songming Huang, Dandan Zhong, Ying Sun and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhenzhen Sun *Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China.ORCID http://orcid.org/0000-0001-9828-7377
Le Sun *Nanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China.
Hu HuaNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China.
Ying RenNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China.
Wenping ZhuNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China.
Xu WangDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, China.
Wei GuDepartment of Endocrinology, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, China.
Songming HuangNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China.ORCID http://orcid.org/0000-0002-1293-0198
Dandan ZhongNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China.
Ying SunNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China. yingsun@xzhmu.edu.cn.ORCID http://orcid.org/0000-0002-1720-8540
Yue ZhangNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China. zyflora2006@hotmail.com.ORCID http://orcid.org/0000-0003-0844-5218
Aihua ZhangNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China. zhaihua@njmu.edu.cn.ORCID http://orcid.org/0000-0001-7438-4404
Zhanjun JiaNanjing Key Laboratory of Pediatrics, Children's Hospital of Nanjing Medical University, Guangzhou Road #72, Nanjing, P. R. of China. jiazj72@hotmail.com.ORCID http://orcid.org/0000-0002-3107-0429

Funding

China Postdoctoral Science Foundation 2022M721684
6 · The paper itself

Abstract

The mode of electron transport in mitochondrial respiratory chain determines whether it generates energy or more reactive oxygen species (ROS), a key for cellular adaptation to diverse oxygen environments. However, the understanding of the mechanisms remains incomplete. Here, we find that NIMA-related kinase 7 (NEK7), targeted to mitochondria by its signal peptides, binds to succinate dehydrogenase complex iron sulfur subunit B (SDHB), stabilizing the spatial conformation of complex II and promoting forward electron transport. Deficiency of NEK7 in hepatocytes induces reverse electron transport (RET) and inhibits mitochondrial respiration, thereby promoting ROS generation, triggering spontaneous liver fibrosis and aggravating CCl

Indexed as

Liver CirrhosisNIMA-Related KinasesSuccinate DehydrogenaseAnimalsCarbon TetrachlorideDiet, High-FatElectron TransportHepatocytesHomeostasisHumansMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaReactive Oxygen SpeciesCarbon TetrachlorideNEK7 protein, humanNIMA-Related KinasesReactive Oxygen SpeciesSDHB protein, humanSuccinate Dehydrogenase

Identifiers

PMID41315267
PMCPMC12663309

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.