Evidence map›Paper›PMID 41315376›Full record

ArticleScientific reports2025

Developmental timing of auditory deprivation influences spatial memory and hippocampal plasticity in rats.

Marjan Mirsalehi, Alimohamad Asghari, Masoud Nasiri Nasab Rafsanjani, Akram Pourbakht, Maryam Balali, Sayedali Ahmadi, Zeinab Akbarnejad

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Marjan Mirsalehi *ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Neyiayesh St., Sattar Khan Ave., P.O. Box 14455-364, Tehran, 1445613131, Iran.
Alimohamad Asghari *ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Neyiayesh St., Sattar Khan Ave., P.O. Box 14455-364, Tehran, 1445613131, Iran.
Masoud Nasiri Nasab RafsanjaniENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Neyiayesh St., Sattar Khan Ave., P.O. Box 14455-364, Tehran, 1445613131, Iran.
Akram PourbakhtRehabilitation Research Center, Department of Audiology, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.
Maryam BalaliENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Neyiayesh St., Sattar Khan Ave., P.O. Box 14455-364, Tehran, 1445613131, Iran.
Sayedali AhmadiDepartment of Neurosurgery, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Zeinab AkbarnejadENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Neyiayesh St., Sattar Khan Ave., P.O. Box 14455-364, Tehran, 1445613131, Iran. akbarnejad.z@iums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-dependent sensory deprivation may differentially affect hippocampal integrity, making it essential to investigate how the timing of exposure influences neurodevelopmental outcomes. This study aimed to examine how peripheral auditory deprivation at various ages impacts cognitive functions in rats. Transcanal cochlear ablation was performed at postnatal days (PND) 14, 21, 28, and 60. At four months of age, spatial learning, memory, neurogenesis, and molecular markers associated with synaptic plasticity were evaluated. Compared to controls, all experimental groups-except those ablated at PND 14-exhibited spatial memory deficits, with the most pronounced impairment observed in animals ablated at PND 28 and 60. Correspondingly, hippocampal neurogenesis and synaptic plasticity were significantly reduced in these groups. These changes were age-dependent, with early-life auditory sensory deprivation causing less significant impairment in adulthood. Our study demonstrated an age-dependent effects of auditory deprivation on hippocampal function. The more pronounced reduction in hippocampal function developed in hearing-deprived animals at older ages compared to animals with early-life cochlear ablation. This highlights the importance of age in understanding the cognitive effects of auditory deprivation.

Indexed as

HippocampusNeuronal PlasticitySensory DeprivationSpatial MemoryAge FactorsAnimalsCochleaMaleNeurogenesisRatsCochlear ablationDevelopmental ageHearing lossNeurogenesisSpatial learning and memorySynaptic plasticity

Identifiers

PMID41315376
PMCPMC12663570

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.