IL-27Ra promotes the progression of neonatal necrotizing enterocolitis.

Yuling Yang, Yingyan Liu, Limei Zhong, Chun Yan, Xin Zhong, Chaoting Lan, Sitao Li, Yufeng Liu

Abstract read

In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Chemokine-receptor-dependent inflammatory responses contribute to two-hit-induced experimental necrotizing enterocolitis and represent a potential therapeutic target.Frontiers in immunology · 2026
Article
Mechanisms by which tryptophan metabolites enhance intestinal barrier function to prevent necrotizing enterocolitis in preterm infants.Frontiers in immunology · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuling Yang *Center for Medical Research On Innovation and Translation, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, 510000, Guangdong, China.

Yingyan Liu *Center for Medical Research On Innovation and Translation, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, 510000, Guangdong, China.

Limei Zhong *Department of Laboratory Medicine, Guangdong Second Provincial General Hospital, Guangzhou, 510317, China.

Chun YanCenter for Medical Research On Innovation and Translation, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, 510000, Guangdong, China.

Xin ZhongGuangzhou Women and Children's Medical Center, Liuzhou Hospital, Liuzhou, 545616, Guangxi, China.

Chaoting LanDepartment of Surgical Neonatal Intensive Care Unit, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510000, Guangdong, China.

Sitao LiDepartment of Pediatrics, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510655, China. lisit@mail.sysu.edu.cn.

Yufeng LiuCenter for Medical Research On Innovation and Translation, Guangzhou First People's Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, 510000, Guangdong, China. eyyufengliu@scut.edu.cn.

Funding

National Natural Science Funds 82171695the Science and Technology Program of Guangzhou SL2024A03J01319

6 · The paper itself

Abstract

Neonatal necrotizing enterocolitis (NEC) is a life-threatening gastrointestinal disease of premature infants, characterized by immune dysregulation and compromised intestinal barrier integrity. Interleukin-27 receptor α (IL-27Ra), a critical component of the JAK-STAT signaling pathway, exhibits dual pro- and anti-inflammatory roles in various inflammatory conditions. However, its role in NEC pathogenesis remains unclear. To elucidate the functional role of IL-27Ra in NEC development and assess its potential as a therapeutic target. A multi-tiered approach was employed, including integrative analysis of clinical NEC specimens by single-cell and bulk RNA sequencing, and a neonatal mouse NEC model. NEC was induced in mice via hyperosmolar formula feeding combined with LPS gavage, intermittent hypoxia, and cold stress. Additional experiments included immunofluorescence staining for IL-27Ra, cytokine profiling (ELISA, quantitative real-time PCR (qPCR)), use of IL-27Ra knockout (IL-27Ra

Indexed as

Enterocolitis, NecrotizingReceptors, CytokineReceptors, InterleukinAnimalsAnimals, NewbornDisease Models, AnimalDisease ProgressionFemaleHumansInfant, NewbornIntestinal MucosaMiceMice, Inbred C57BLMice, KnockoutSignal TransductionIL27RA protein, humanIl27ra protein, mouseReceptors, CytokineReceptors, InterleukinIL-27RaIntestinal barrierIntestinal inflammationNeonatal immunityNeonatal necrotizing enterocolitis

Identifiers

PMID41315384

DOI10.1038/s41598-025-26899-w

PMCPMC12663434

What Socratic holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.