Evidence map›Paper›PMID 41315395›Full record

ArticleNature communications2025

Avian GCGR-mediated continuous fat utilization offers perspectives for obesity treatment.

Chang Zhang, Xue Wang, Chenxi Feng, Huaping Zheng, Song Leng, Yiheng Jiang, Qian Sun, Xiaoou Li, Ting Zhang, Jiacheng Zhang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Chang Zhang *Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Xue Wang *Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Chenxi Feng *Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Huaping Zheng *Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID 0000-0002-0716-8987
Song Leng *Department of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Yiheng JiangDepartment of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Qian SunDepartment of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID 0000-0002-9532-3042
Xiaoou LiDepartment of Pulmonary and Critical Care Medicine, Division of Pulmonary Diseases, State Key Laboratory of Biotherapy, West China Hospital, West China School of Medicine, Sichuan University, Chengdu, 610041, China.
Ting ZhangJiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
Jiacheng ZhangDepartment of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID 0009-0003-6776-0370
Haidi ChenDepartment of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.
Shanshan LaiJiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.
Wojciech MakalowskiInstitute of Bioinformatics, Faculty of Medicine, University of Münster, Münster, 48149, Germany.ORCID 0000-0003-2303-9541
Jürgen BrosiusDepartment of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID 0000-0003-1650-2059
Yujun ShiDepartment of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China.ORCID 0000-0003-0494-6023
Yang HeTargeted Tracer Research and Development Laboratory, Institute of Respiratory Health, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China. heyangqx@scu.cn.ORCID 0000-0002-9241-5101
Peng HuKey Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Ministry of Education), Shanghai Ocean University, Shanghai, 200082, China. phu@shou.edu.cn.ORCID 0009-0002-6840-7758
Qiu SunState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and Collaborative Innovation Center of Biotherapy, Sichuan University, Chengdu, 610041, China. sunqiu@scu.edu.cn.ORCID 0000-0001-5122-2226
Cheng DengDepartment of High Altitude Medicine, Center for High Altitude Medicine, National Clinical Research Center for Geriatrics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, China. dengcheng@wchscu.cn.ORCID 0000-0002-5296-8879

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32270438
6 · The paper itself

Abstract

Human obesity is the fifth leading cause of global mortality. Fat mass loss and maintenance are central challenges for obesity management. In contrast, birds exhibit modest weight gain and limited fat accumulation due to rapid fat utilization as flight fuel. The physiology of this adaptation remained a mystery for a century. Here we show that cross-species single-nucleus RNA-sequencing analysis revealed high GCGR expression levels in avian adipocytes, while minimal in the adipose tissue of other vertebrates. Avian GCGR employs a unique rapid fat utilization mechanism for retaining a light body. Avian GCGR or other constitutively active GCGR variants (human GCGR

Indexed as

Avian ProteinsObesityAdipocytesAdipose TissueAdipose Tissue, WhiteAnimalsBirdsChickensHumansMaleMiceMice, Inbred C57BLWeight LossAvian Proteins

Identifiers

PMID41315395
PMCPMC12754057

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.