SynthesisScientific reports2025
Association of noninvasive tests of liver fibrosis with chronic kidney disease in MASLD: a systematic review and meta-analysis.
Synthesis in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabolic dysfunction-associated steatotic liver disease (MASLD) is an emerging risk factor for chronic kidney disease (CKD). While liver biopsy is the gold standard for assessing fibrosis, noninvasive tests (NITs)-including fibrosis-4 (FIB-4), nonalcoholic fatty liver disease fibrosis score (NFS), and vibration-controlled transient elastography-are validated alternatives. However, their association with CKD stage in MASLD remains unclear. This study aimed to evaluate the association between NITs and various CKD outcomes in MASLD. A systematic search identified observational studies published between January 2014 to July 2024 following PRISMA were included. Data extraction and risk-of-bias assessment were performed independently by multiple reviewers. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random-effects model. A total of 33 studies comprising 278,355 MASLD were included. High FIB-4 were associated with increased risks of CKD stage ≥ 3 (adjusted OR (AOR): 2.23; 95%CI 1.40-3.53) and advanced CKD including ESRD (OR: 2.75; 95%CI 1.27-5.96). High NFS was associated with albuminuria (AOR: 1.68; 95%CI 1.19-2.38) and CKD stage ≥ 3 (AOR: 2.52; 95%CI 1.78-3.58). Elevated liver stiffness showed a strong association with CKD stage ≥ 3 (AOR: 3.12; 95%CI 2.16-4.49). NITs may serve as indicators of CKD staging in MASLD. Future studies should explore whether targeting liver fibrosis could mitigate CKD progression.
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