Evidence map›Paper›PMID 41315496›Full record

ArticleScientific reports2025

Enhanced glycolysis and nicotinamide metabolism in HPV-positive head and neck cancer.

Katie A Shen, Jae-Jin Lee, Shu-Yun Cheng, Ella P Jackert, Liyang Tang, Daniel Kwon, Niels Kokot, Uttam Sinha, Yang Chai, Hyungjin Eoh and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katie A ShenKeck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Jae-Jin LeeDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Shu-Yun ChengCaruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 San Pablo St. #5800, Los Angeles, CA, 90033, USA.
Ella P JackertKeck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Liyang TangCaruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 San Pablo St. #5800, Los Angeles, CA, 90033, USA.
Daniel KwonCaruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 San Pablo St. #5800, Los Angeles, CA, 90033, USA.
Niels KokotCaruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 San Pablo St. #5800, Los Angeles, CA, 90033, USA.
Uttam SinhaCaruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 San Pablo St. #5800, Los Angeles, CA, 90033, USA.
Yang ChaiHerbert Ostrow School of Dentistry of USC, University of Southern California, Los Angeles, CA, 90033, USA.
Hyungjin EohDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Albert Y HanCaruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine, University of Southern California, 1540 San Pablo St. #5800, Los Angeles, CA, 90033, USA. albert.han@med.usc.edu.

Funding

Interplay of M. tuberculosis trehalose metabolism and its pathogenesis and drug resistanceR01AI168088 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Hyungjin Eoh · 2023 to 2026
$2.6M
NIAID NIH HHS R01 AI168088
6 · The paper itself

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the seventh most common cancer globally, with increasing prevalence driven largely by human papillomavirus (HPV) infection. Current standard therapies frequently leave patients with severe, long-term functional impairments, significantly reducing quality of life. Although HPV-positive HNSCC has improved prognosis and better treatment responses compared to HPV-negative disease, the underlying metabolic distinctions remain poorly defined. Using comprehensive metabolomic profiling via ultra-performance liquid chromatography-mass spectrometry in well-established HPV-positive (SCC47, SCC104) and HPV-negative (Detroit562, SCC9) HNSCC cell lines, we demonstrate for the first time through comprehensive metabolomic analysis that HPV-positive HNSCC uniquely enhances metabolic pathways advantageous for rapid cell proliferation, including glycolysis and nicotinamide metabolism. Conversely, HPV-negative HNSCC primarily relies on downstream components of the tricarboxylic acid cycle for energy production. Identifying these differential metabolic has important implications for precision-oncology in the development of targeted therapeutics for HPV-positive HNSCC patients.

Indexed as

GlycolysisHead and Neck NeoplasmsNiacinamidePapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckCell Line, TumorCell ProliferationHumansMetabolomicsPapillomaviridaeNiacinamideHead and neck cancerHuman papillomavirusMetabolismMetabolomicsWarburg effect

Identifiers

PMID41315496
PMCPMC12663544

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.