Essential oils from Artemisia judaica, Ruta graveolens and Salvia palaestina with antiradical, cytotoxic and AMPA receptor-modulatory activities.

Mohammad Qneibi, Nidal Jaradat, Othman Hamed, Mohammed Hawash, Murad Abualhasan, Mohammad Qadi, Sosana Bdir

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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7 authors.

Mohammad QneibiDepartment of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Health Sciences, An-Najah National University, Nablus, P400, Palestine. mqneibi@najah.edu.

Nidal JaradatDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An-Najah National University, Nablus, P400, Palestine. nidaljaradat@najah.edu.

Othman HamedDepartment of Chemistry, Faculty of Science, An-Najah National University, Nablus, P400, Palestine.

Mohammed HawashDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An-Najah National University, Nablus, P400, Palestine.

Murad AbualhasanDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An-Najah National University, Nablus, P400, Palestine.

Mohammad QadiDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An-Najah National University, Nablus, P400, Palestine.

Sosana BdirDepartment of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Health Sciences, An-Najah National University, Nablus, P400, Palestine.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Essential oils (EOs) from the leaves of Artemisia judaica, Ruta graveolens, and Salvia palaestina were analyzed for their phytochemical composition and their antiradical, cytotoxic, and neuromodulatory activities. Using microwave-ultrasonic technology, EOs were extracted from S. palaestina, A. judaica, and R. graveolens, and their antiradical activity (via DPPH assay), cytotoxicity, and neuromodulatory effects (using whole-cell patch-clamp recordings) were evaluated. The main compounds that were explored by GC-MS analysis include piperitone and carvacrol in A. Judaica, 2-undecanone in R. graveolens, and carvacrol in S. palaestina. S. palaestina exhibited the greatest antiradical effect with a 50% inhibition concentration of 8.30 µg/mL. Cytotoxicity tests showed that these EOs express dose-dependent activity on HeLa, HepG3, and B16F1 cancer cells. Among them, S. palaestina and A. judaica were the most potent ones. Patch-clamp recordings showed that S. palaestina was the most potent in inhibiting action toward AMPA receptors, thereby reducing currents up to 6-fold and modulating receptor kinetics. A. Judaica and R. graveolens also inhibited the AMPA receptor activity, but to a lesser extent. These findings point to the important bioactive potential of these EOs, especially S. palaestina, which demonstrated high antiradical and AMPA receptor-modulatory activities and, thus, could be of interest for pharmaceutical and neuroprotective uses.

Indexed as

ArtemisiaOils, VolatileReceptors, AMPARutaSalviaAnimalsAntioxidantsCell Line, TumorCell SurvivalFree Radical ScavengersHeLa CellsHumansMicePlant ExtractsPlant LeavesAntioxidantsFree Radical ScavengersOils, VolatilePlant ExtractsReceptors, AMPAAMPA receptorAntiradicalCytotoxicityDesensitizationPhytochemical composition

Identifiers

PMID41315747

DOI10.1038/s41598-025-30649-3

PMCPMC12753767

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.