Evidence map›Paper›PMID 41315749›Full record

ArticleInternational journal of obesity (2005)2026

Post-intervention sustainability of time-restricted eating versus caloric restriction: a secondary analysis.

De-An Chen, Raul Herrera Pena, Niki Oldenburg, Qi Wang, Erika Helgeson, Brad Yentzer, Abdisa Taddese, Nicole LaPage, Emily N C Manoogian, Satchinananda Panda and 1 more

Registry-linked trialAbstract read
In one paragraph

Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04259632 (Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04259632 nacompletednot on this map

Prolonged Daily Fasting as a Viable Alternative to Caloric Restriction in At-Risk Obese Humans

TypeinterventionalSponsorUniversity of MinnesotaRan2020 to 2025Enrolled115ConditionsObesityArmsTime Restricted Eating (TRE), Caloric Restriction (CR)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

De-An Chen *Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Raul Herrera Pena *Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Niki OldenburgDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Qi WangClinical and Translational Science Institute, University of Minnesota, Minneapolis, MN, USA.
Erika HelgesonSchool of Public Health, University of Minnesota, Minneapolis, MN, USA.
Brad YentzerDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Abdisa TaddeseDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Nicole LaPageDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA.
Emily N C ManoogianSalk Institute for Biological Sciences, San Diego, CA, USA.ORCID 0000-0001-9718-9310
Satchinananda PandaSalk Institute for Biological Sciences, San Diego, CA, USA.
Lisa S ChowDepartment of Medicine, University of Minnesota, Minneapolis, MN, USA. chow0007@umn.edu.ORCID 0000-0002-6210-2307

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger, KAMIL UGURBIL · 2019 to 2026
$11.7M
Prolonged Daily Fasting As a Viable Alternative to Caloric Restriction in At-Risk Obese HumansR01DK124484 · NIDDK · UNIVERSITY OF MINNESOTA · PI CHOW, LISA SENYE · 2020 to 2023
$2.7M
NCATS NIH HHS UM1TR004405-01A1NIBIB NIH HHS P41 EB027061NIDDK NIH HHS R01 DK124484
6 · The paper itself

Abstract

Rising obesity rates necessitate sustainable weight management strategies. Current lifestyle guidelines focus on reducing caloric intake through personalized interventions to promote compliance. This secondary analysis evaluated post-intervention sustainability of time-restricted eating (TRE) versus caloric restriction (CR), hypothesizing that TRE's "watching the clock" approach may be more sustainable than CR's "watching calories." Following a 12-week supervised intervention (TRE: 8-h eating window, n = 29; CR: 15% caloric reduction, n = 26), 41 participants (75%; 24 F/17 M; 23 TRE/18 CR; age 43.1 ± 11.6 years; BMI 34.7 ± 5.4 kg/m²) completed follow-up surveys at 1, 3, and 6 months. TRE participants maintained weight across all follow-ups compared to final intervention weight. CR participants showed significant loss at 1 month (-1.6 ± 2.5 kg, p = 0.02), returning to baseline by 3 months. Both interventions had similar continuation rates (1,3,6 months: TRE: 52%, 36%, 47%; CR: 63%, 57%, 50%; p = 0.60) and recommendation rates (TRE: 81%, 85%, 86%; CR: 88%, 86%, 80%; p = 0.72). TRE participants reported improved sleep, energy, and digestion but experienced morning hunger and scheduling challenges. CR participants noted increased food mindfulness but reported tracking anxiety, cravings, and potential binge eating. Despite limitations including small sample size and self-reported weight, both self-sustained TRE and CR showed similar acceptability and weight maintenance at 3-6 months post-intervention. Clinical Trial Registration: Clinicaltrials.gov NCT04259632.

Indexed as

Caloric RestrictionFastingFeeding BehaviorObesityAdultEnergy IntakeFemaleHumansMaleMiddle AgedWeight Loss

Identifiers

PMID41315749
PMCPMC12913024

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.