ArticleBMC plant biology2025
Integrated transcriptome, metabolome and activity-guided fractionation of Parnassia wightiana Wall. reveal its insecticidal potential.
Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundParnassia wightiana Wall. (P. wightiana) is a traditional medicinal herb with demonstrated potential for developing eco-friendly botanical insecticides, but its insecticidal properties remain underexplored.
methodsHere, we systematically evaluated the insecticidal activities of different plant tissues through integrated bioactivity assays and metabolomic profiling. Combining bioactivity-guided fractionation with transcriptomic analysis, we identified bioactive insecticidal compounds and elucidated key genes involved in secondary metabolite biosynthesis.
resultsBioassays revealed that root extracts exhibited the highest insecticidal efficacy against third-instar Mythimna separata (M. separata) larvae, with a median lethal concentration (LC
conclusionsThese findings advance our understanding of insecticidal metabolite biosynthesis in P. wightiana and provide a foundation for metabolic engineering of insecticidal compounds, and development of novel biopesticides with reduced environmental impact.
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