Evidence map›Paper›PMID 41316093›Full record

ArticleBMC public health2025

U.S. public perceptions on whether risk of dementia and stroke can be modified through maintaining or changing lifestyle.

Jasper R Senff, Mark Jun Shah-Ostrowski, Reinier W P Tack, Courtney Nunley, Caroline R Palys, Sharon Ng, Akashleena Mallick, Leidys Gutierrez-Martinez, Jonathan Duskin, Tamara N Kimball and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Jasper R SenffBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Mark Jun Shah-OstrowskiNuffield Department of Population Health, University of Oxford, Oxford, UK.
Reinier W P TackBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Courtney NunleyBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Caroline R PalysBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Sharon NgBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Akashleena MallickBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Leidys Gutierrez-MartinezBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Jonathan DuskinBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Tamara N KimballBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Savvina PrapiadouBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Sandro MariniBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Evy ReindersBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Katelin ShermanBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Ayneisha TinobleBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
H Bart BrouwersDepartment of Neurology and Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands.
Setareh AkhavanLA County Department of Health Services, Los Angeles, CA, USA.
Amytis TowfighiLA County Department of Health Services, Los Angeles, CA, USA.
Cyprien A RivierDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Guido J FalconeDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Kevin ShethDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Ronald M LazarMCKnight Brain Institute, Department of Neurology, School of Medicine, University of Alabama, Birmingham, AL, USA.
Sarah IbrahimProgram for Health System and Technology Evaluation, Department of Neurology, Toronto General Hospital Research Institute, Toronto Western Hospital, Toronto, ONT, Canada.
Aleksandra PikulaJay and Sari Sonshine Centre for Stroke Prevention and Cerebrovascular Brain Health, Krembil Brain Institute, University Health Network, Toronto, ONT, Canada.
Zeina ChemaliMcCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Cornelia van DuijnNuffield Department of Population Health, University of Oxford, Oxford, UK.
Gregory FricchioneMcCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Rudolph E TanziMcCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Nirupama YechoorBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Christopher D AndersonBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Valerie Purdie GreenawayDepartment of Psychology, Columbia University, New York, NY, USA.
Koen B PouwelsNuffield Department of Population Health, University of Oxford, Oxford, UK.
Jonathan RosandBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA.
Sanjula Dhillon SinghBrain Care Labs, Department of Neurology, Massachusetts General Brigham, Boston, MA, USA. ssingh32@mgh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiological studies suggest that approximately 40% of dementia and 60% of stroke cases could be prevented through adequate control of modifiable risk factors. Limited data are available on the public perceptions in the United States (U.S.) on whether the risk of dementia and stroke can be modified through lifestyle changes.

methodsA survey utilizing questions from validated questionnaires was distributed to a sample of the general U.S. POPULATION: We performed multivariable logistic regression analyses for which the binary exposure was ever having known someone with dementia or stroke, and the primary outcomes were the perceptions on whether dementia and stroke risk could be modified through maintaining or changing lifestyle.

resultsWe included 1,478 participants (mean [SD] age: 45.5 [15.9], 51.1% female), of whom 80% (N = 1185) ever knew someone with dementia or stroke. Over 75% of all participants perceived that a healthy lifestyle can lower dementia and stroke risks. Following multivariable analyses, participants who ever knew someone with dementia or stroke were more likely to agree that maintaining (adjusted Odds Ratio [aOR] = 1.41, 95%CI:1. 10-1.96) and that changing lifestyle (aOR = 1.59, 95%CI:1.14-2.24) reduces dementia risk, when adjusted for age, sex assigned at birth, race/ethnicity, level of education, employment status, and being a caregiver for someone with dementia or stroke. Participants who knew someone with dementia or stroke were also more likely to agree that maintaining (aOR = 1.77, 95%CI:1.27-2.47) or changing lifestyle (aOR = 2.31, 95%CI:1.41-3.76) reduces stroke risk when adjusted for similar confounders. DISCUSSION: This cross-sectional cohort, mimicking the general U.S. population, demonstrated that over 80% of individuals ever knew someone with dementia or stroke and that this was positively associated with the perceptions that dementia and stroke risk could be modified through lifestyle changes. The widespread exposure of the U.S. public to dementia and stroke first-hand can be leveraged into more effective preventive strategies.

Indexed as

DementiaHealth Knowledge, Attitudes, PracticeLife StylePublic OpinionRisk Reduction BehaviorStrokeAdultAgedFemaleHumansMaleMiddle AgedRisk FactorsSurveys and QuestionnairesUnited States

Identifiers

PMID41316093
PMCPMC12664128

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.