ArticleBMC public health2025
Association among persistent chemical pollutants and infectious encephalitis: a mixture exposure and mediation approach.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMost overlook the harmful effects on diseases, particularly the chronic neurotoxicity, which remains undetermined. This study aims to determine the impact of major environmental factors on infectious encephalitis.
methodsOur study investigated the correlation between persistent chemical pollutants and reports and mortality cases of infectious encephalitis (Epidemic cerebrospinal meningitis and Encephalitis B). First, the quantile-based g computation (qgcomp) statistical method was used to analyze the correlation of different chemical pollutants. Bayesian Kernel Machine Regression-Causal Mediation Analysis (BKMR-CMA) method was applied to explore the mediating effect of greenhouse gases between persistent chemical pollution mixtures and incidence and mortality of infectious encephalitis. Finally, the Lasso regression method was used to assess the sensitivity of different age groups of encephalitis patients to the risks of different chemical pollutants.
resultsFor epidemic cerebrospinal meningitis report cases, N
conclusionsWe found that most persistent chemical pollutants in the air increase the risk of neurotoxicity-related morbidity and mortality. Among them, epidemic cerebrospinal meningitis is primarily driven by PCB and OC, while encephalitis B is mainly driven by CH
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