ArticleBMC sports science, medicine & rehabilitation2025
Exercise as a modulator of systemic inflammation and oxidative stress biomarkers across clinical and healthy populations: an umbrella meta-analysis.
Article in BMC sports science, medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07662954 (Effects of Magnesium Supplementation and Spinning Training on Cardiac Function, Oxidative Stress, Inflammation, and Aerobic Capacity), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Magnesium Supplementation and Spinning Training on Cardiac Function, Oxidative Stress, Inflammation, and Aerobic Capacity
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparative effects of weight-loss diet, exercise training, respiratory muscle training, and oropharyngeal muscle training in obstructive sleep apnea: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
- Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review).International journal of molecular medicine · 2026Review
- Skeletal Muscle Redox Signaling in Health and Disease: From Molecular Mechanisms to Therapeutic Exercise Strategies.Antioxidants (Basel, Switzerland) · 2026Review
- Effect of Moderate Aerobic Exercise on Body Composition, Biochemical Parameters and Oxidative Damage in Older Women Without and With Metabolic Syndrome.Journal of functional morphology and kinesiology · 2026Article
- Age-Dependent Differences in Exercise Response Among Healthy Women: Impact on Inflammation, Lipids Profile and Glucose.Biomedicines · 2026Article
- Joint associations between exercising and classical cardiometabolic risk factors with all-cause, premature and cardiovascular mortality: a prospective cohort study among Mexican adults.Frontiers in endocrinology · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInflammation is a condition that trigger an immune response and oxidative stress refers to an imbalance between production and elimination of reactive oxygen species (ROS). However, several non-pharmacological approaches have been proposed to improve health outcomes, among which exercise programs have shown promising effects on inflammatory and oxidative biomarkers across various health conditions.
aimIn this regard, the present umbrella meta-analysis aimed to evaluate the potential of exercise interventions to modulate inflammatory and oxidative stress biomarkers across different population.
methodsA comprehensive systematic search was carried out in on Scopus, PubMed, Embase, Web of Science, and Google Scholar up to March 2025. The overall effect size (ESs) was calculated using random effect model. Also, subgroup analyses were performed regarding ESs, health status, ad type of exercise program.
resultsOur comprehensive systematic search initially identified 1246 studies, of which twenty-nine meta-analyses, were included in the present umbrella meta-analysis. Finding revealed that training program could significantly reduce C-reactive protein (CRP) (ES: -0.50; 95% CI: -0.65, -0.36, P < 0.001), interleukin-6 (IL-6) (E: -0.29; 95% CI: -0.41, -0.18; P < 0.001), IL-8 (ES: -1.20; 95% CI: -2.19, -0.21, P = 0.018), tumor necrosis factor-α (TNF-α) (ES: -0.47, 95% CI: -0.60, -0.34; P < 0.001). In addition, it was accompanied with an improvement in malondialdehyde (MDA) (ES: -1.26; 95% CI: -1.60, -0.93, P < 0.001) and glutathione peroxidase (GPx) (ES: 0.88, 95% CI: 0.25, 1.51; P = 0.006) level too. Subgroup analyses indicated that all aerobic, resistance and combined exercise could improve inflammatory state significantly. Also, exercise favorable properties were evident in most health state to affect CRP, IL-6, and TNF-α level.
conclusionExercise program could attenuate the CRP, IL-6, IL-8 and TNF-α level. Additionally, exercise demonstrated a beneficial impact on oxidative status, as evidenced by decreased MDA levels and increased GPx activity.
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