ArticleRadiation oncology (London, England)2025
Partial abdominal carbon-ion FLASH irradiation spares lethality compared to conventional irradiation: impact of LET and dose rate.
Article in Radiation oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Preliminary mechanistic study of mitochondrial function in intestinal protection mediated by high-energy X-ray FLASH radiotherapy.Radiation oncology (London, England) · 2026Article
- Microenvironmental remodeling in FLASH radiotherapy.Frontiers in cell and developmental biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
backgroundUltra-high dose rate (FLASH) therapy has attracted attention for its potential to effectively target tumors while preserving healthy tissues. Although the biological effects of FLASH therapy have been well-documented with electrons, photons, and protons, data regarding carbon-ions are limited. This study aimed to investigate the biological effects of carbon-ions on the intestines of mice to determine whether carbon-ions exhibit the FLASH effect. Simultaneously, we aimed to identify the parameters influencing its occurrence. MATERIALS AND
methodsPartial abdominal irradiation was performed on C3H/He mice using 290 MeV/u FLASH and conventional dose rate (CONV) carbon-ions under both low and high linear energy transfer (LET). The evaluation included the 30-day survival rate, body weight changes, and stool pellet alterations within 14 days after irradiation. Furthermore, we assessed the number of regenerating crypts 3.5 days after irradiation.
resultsUnder low-LET, FLASH and CONV irradiation exhibited comparable sparing effects on normal intestinal tissues. However, FLASH significantly improved the survival rate of mice under high-LET, when the dose rate exceeded 100 Gy/s. The number of regenerating crypts 3.5 days after irradiation was 1.5 times higher in the FLASH group than in the CONV group.
conclusionsThe results indicate that carbon-ion FLASH exhibits the FLASH effect at high-LET with dose rate and LET identified as critical parameters influencing the FLASH effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.