Evidence map›Paper›PMID 41316350›Full record

ArticleRespiratory research2025

Susceptibility to childhood asthma modified by the interactive effects of polycyclic aromatic hydrocarbons exposure and genetic polymorphisms of the aryl hydrocarbon receptor signaling pathway: functional analysis based on lipid metabolism.

Xuna Tao, Xinfeng Xu, Xinyao Jiang, Mingcong Chen, Yuling Bao, Shuyuan Cao, Lei Li, Sheng Yang, Qian Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuna Tao *China International Cooperation Center (CCC) for Environment and Human Health and Department of Health Inspection and Quarantine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Xinfeng Xu *China International Cooperation Center (CCC) for Environment and Human Health and Department of Health Inspection and Quarantine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Xinyao JiangChina International Cooperation Center (CCC) for Environment and Human Health and Department of Health Inspection and Quarantine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Mingcong ChenDepartment of Physical and Chemical Inspection, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, 210003, China.
Yuling BaoDepartment of Respiratory Medicine, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China.
Shuyuan CaoChina International Cooperation Center (CCC) for Environment and Human Health and Department of Health Inspection and Quarantine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Lei LiChina International Cooperation Center (CCC) for Environment and Human Health and Department of Health Inspection and Quarantine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Sheng YangDepartment of Biostatistics, Centre for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. yangsheng@njmu.edu.cn.
Qian WuChina International Cooperation Center (CCC) for Environment and Human Health and Department of Health Inspection and Quarantine, School of Public Health, Nanjing Medical University, Nanjing, 211166, China. wuqian@njmu.edu.cn.

Funding

National Natural Science Foundation of China 82073630National Natural Science Foundation of China 82273741
6 · The paper itself

Abstract

Exposure to polycyclic aromatic hydrocarbons (PAHs) is linked to the development of childhood asthma, but little is known about PAH exposure-single nucleotide polymorphisms (SNPs) involved in the aryl hydrocarbon receptor (AHR) signaling pathway interactions on childhood asthma. This study aimed to investigated the effects of PAH exposure interactions with SNPs in the AHR signaling pathway on childhood asthma and characterized the molecular pathway of asthma genetic risk based on the metabolome. A total of 370 children were included in the current study. Serum fluoranthene, benz(a)anthracene, chrysene, benzo(k)fluoranthene and benzo(a)pyrene levels were significantly associated with childhood asthma. SNP genotyping analysis revealed that CYP1A1 rs4646421 was significantly associated with childhood asthma (OR: 2.404, 95% CI: 1.542-3.747) in Chinese children. Generalized multifactor dimensionality reduction analysis showed significant interactions between PAH exposure and rs4646421, increasing the risk of childhood asthma. Expression quantitative trait loci analysis showed that the rs4646421-AA genotype was significantly associated with the increased expression of CYP1A1. Mediation analysis identified six serum lipid metabolites associated with rs4646421 that mediated the effect of the rs4646421-AA genotype on childhood asthma. To verify the potential biological function of rs4646421, a model of CYP1A1-overexpressing human bronchial epithelial cells was constructed. The results showed that CYP1A1 overexpression downregulated serine palmitoyl transferase expression by decreasing AHR/ARNT2 levels, and subsequently reduced C16-ceramide synthesis and upregulated the expression of inflammatory factors associated with asthma in the human bronchial epithelial cells. This study provided the evidence of the interactions between PAH exposure and CYP1A1 rs4646421 in increasing childhood asthma susceptibility in Chinese, suggesting that rs4646421 played a functional role in childhood asthma by affecting the expression of CYP1A1, thereby interfering with lipid metabolism.

Indexed as

AsthmaEnvironmental ExposureGenetic Predisposition to DiseaseLipid MetabolismPolycyclic Aromatic HydrocarbonsPolymorphism, Single NucleotideReceptors, Aryl HydrocarbonSignal TransductionBasic Helix-Loop-Helix ProteinsChildChild, PreschoolCytochrome P-450 CYP1A1FemaleHumansMaleAHR protein, humanBasic Helix-Loop-Helix ProteinsCYP1A1 protein, humanCytochrome P-450 CYP1A1Polycyclic Aromatic HydrocarbonsReceptors, Aryl HydrocarbonAryl hydrocarbon receptor signaling pathwayChildhood asthmaInteractionLipid metabolismPolycyclic aromatic hydrocarbonsSingle nucleotide polymorphisms

Identifiers

PMID41316350
PMCPMC12765307

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.