SynthesisJournal of neuroengineering and rehabilitation2025
Neuromodulation effects of low-intensity transcranial focused ultrasound in human, a systematic review focusing on motor and sensory functions.
Synthesis in Journal of neuroengineering and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Trial
- Non-invasive neuroregulation techniques applied to patients with consciousness disorders: a narrative review.Frontiers in human neuroscience · 2026Review
- Parameter-Determined Effects: Advances in Transcranial Focused Ultrasound for Modulating Neural Excitation and Inhibition.Bioengineering (Basel, Switzerland) · 2025Review
- Assessing upper motor neuron dysfunction in ALS: from TMS-EEG and EMG neurophysiology to a combined tFUS-TMS translational framework.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundLow-intensity transcranial focused ultrasound (tFUS) has emerged as a novel non-invasive brain stimulation technique with therapeutic potential for various neurological conditions. However, its parameter-dependent bimodal neuromodulatory effects remain to be fully elucidated.
objectiveThis study aims to review the evidence on tFUS-induced neuromodulation in humans, particularly its effects on motor and sensory functions, to identify specific stimulation parameters associated with excitatory and inhibitory outcomes, thereby informing future clinical applications.
methodsA systematic review was conducted using Web of Science and PubMed, including primary interventional human studies on tFUS and neuromodulation published up to December 2024. Eligible studies comprised single-arm trials, quasi-experimental studies, and randomized controlled trials focusing on excitatory and inhibitory effects and specific ultrasound parameters.
resultsThe findings summarize the current evidence on tFUS-induced neuromodulation of motor and sensory functions. Both excitatory and inhibitory effects were observed, particularly in the primary motor cortex, primary somatosensory cortex, thalamus, insula, and dorsal cingulate gyrus. These effects appear to be modifiable through specific stimulation parameters.
conclusionstFUS demonstrates both online/ offline excitatory/ inhibitory effects on sensory and motor brain regions under specific stimulation conditions. It holds promise as a potential therapeutic strategy for managing motor and sensory dysfunctions, such as stroke and chronic pain. However, the underlying mechanisms remain incompletely understood, necessitating further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.