Evidence mapPaperPMID 41316456Full record

ReviewStem cell research & therapy2025

Stem cell therapy: a novel frontier in the treatment of liver fibrosis/cirrhosis.

Yang Liu, Jiacen Li, Wenjie Su, Shuang Wang

Abstract readReview
In one paragraph

Review in Stem cell research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yang Liu *Department of Anesthesiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Jiacen Li *Department of Anesthesiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Wenjie SuDepartment of Anesthesiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. yangcp86@163.com.
Shuang WangDepartment of Geriatrics, People's Hospital of Chang Shou, Chongqing, 401220, China. s22225442@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver fibrosis and cirrhosis are characterized by the excessive accumulation of extracellular matrix (ECM) in the liver, and they represent significant global health concerns due to their increasing prevalence worldwide. Traditional therapeutic approaches, such as liver transplantation, are limited by donor availability and potential complications. Stem cell therapy has emerged as a promising alternative, offering the potential for liver regeneration and repair. This paper reviews the latest advancements in stem cell therapy for liver fibrosis and cirrhosis, drawing from recent clinical trials and laboratory studies. We explore various stem cell types, evaluating their efficacy, safety, and mechanisms of action in liver repair. Our findings suggest that stem cell therapy, with its anti-fibrotic properties, immunomodulatory effects, and ability to promote hepatocyte regeneration, holds significant promise for the future of liver disease treatment.

Indexed as

Liver CirrhosisStem Cell TransplantationAnimalsHumansLiver RegenerationStem CellsCirrhosisLiver fibrosisStem cell therapy

Identifiers

PMID41316456
PMCPMC12763969

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.