Evidence map›Paper›PMID 41316719›Full record

ArticleAnnals of neurology2026

Thrombectomy versus Medical Management for Pediatric Acute Ischemic Stroke Due to Isolated M2 Occlusion: A Multicenter Cohort Study.

Peter B Sporns, Kartik D Bhatia, Prakash Muthusami, Carmen Parra-Farinas, Christine K Fox, Adam A Dmytriw, Basile Kerleroux, Sarah Lee, Jens Fiehler, Christian Lehmann and 15 more

Abstract readMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Peter B SpornsDepartment of Radiology and Neuroradiology, Stadtspital Zürich, Zürich, Switzerland.ORCID 0000-0002-3028-0539
Kartik D BhatiaChildren's Hospital at Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.
Prakash MuthusamiDivision of Paediatric Interventional Neuroradiology, Hospital for Sick Children, Toronto, ON, Canada.
Carmen Parra-FarinasDivision of Paediatric Interventional Neuroradiology, Hospital for Sick Children, Toronto, ON, Canada.
Christine K FoxDepartment of Neurology and Department of Pediatrics, University of California San Francisco, San Francisco, CA, USA.
Adam A DmytriwNeurointerventional and Neuroanalytics Collaboration (NAN-C), School of Medicine, Toronto Metropolitan University, Toronto, ON, Canada.ORCID 0000-0003-0131-5699
Basile KerlerouxDepartment of Neuroradiology, APHM La Timone, Marseille, France.ORCID 0000-0003-0642-3955
Sarah LeeDivision of Child Neurology, Department of Neurology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-8821-6636
Jens FiehlerDepartment of Diagnostic and Interventional Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Christian LehmannDepartment of Radiology and Neuroradiology, Stadtspital Zürich, Zürich, Switzerland.
Franja DugarDepartment of Radiology and Neuroradiology, Stadtspital Zürich, Zürich, Switzerland.
Todd AbruzzoDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ, USA.
Lisa PabstDivision of Pediatric Neurology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake, UT, USA.
Stuart FraserDivision of Child and Adolescent Neurology, Department of Pediatrics, The University of Texas McGovern Medical School, Houston, TX, USA.ORCID 0000-0003-4390-0490
Lisa R SunDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-4948-0415
Grégoire BoulouisDiagnostic and Interventional Neuroradiology DepartmentCIC-IT 1415, CHRU de Tours Université de Tours, INSERM, Imaging Brain and Neuropsychiatry iBraiN U1253, Tours, France.
Tanja BurkardDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.
Olivier NaggaraPediatric Radiology Department, Necker Enfants Malades (NEM), INSERM UMR1266, Sainte-Anne, Paris, France.
Manoelle KossorotoffDepartment of Pediatric Neurology, French Center for Pediatric Stroke, NEM, Paris, France.
André KemmlingDepartment of Neuroradiology, University Hospital Marburg, Marburg, Germany.
Martin OlivieriPediatric Thrombosis and Hemostasis Unit, Dr. von Hauner Children's Hospital, LMU Munich, Munich, Germany.
Mesha MartinezDepartment of Radiology, Texas Children's Hospital, Baylor College of Medicine, Austin, TX, USA.
Marios PsychogiosDepartment of Neuroradiology, University Hospital Basel, Basel, Switzerland.
Thi Dan Linh Nguyen-KimDepartment of Radiology and Neuroradiology, Stadtspital Zürich, Zürich, Switzerland.
Moritz WildgruberDepartment of Radiology, LMU University Hospital, LMU Munich, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEndovascular thrombectomy (EVT) is increasingly used for pediatric large vessel occlusion (LVO) stroke, however, its role in isolated M2 occlusions remains underexplored. This study compared clinical outcomes in children with isolated M2 occlusion treated with EVT versus best medical therapy (BMT).

methodsThis multicenter cohort study pooled data from 4 pediatric stroke registries (Save ChildS, KidClot, Pediatric LVO Study, and Save ChildS Pro). Children ages 28 days-17 years with isolated M2 occlusion presenting within 24 hours of last seen well were included. Primary outcome was the pediatric modified Rankin scale (ped-mRS) at 3 to 6 months. Secondary outcomes included changes in Pediatric National Institutes of Health Stroke Scale (PedNIHSS), Pediatric Stroke Outcome Measure (PSOM), and safety endpoints.

resultsForty patients were included, of whom 20 were treated with EVT (median age, 12 years; interquartile range [IQR], 6-15; 40% female) and 20 with BMT only (10 years; IQR, 5-14; 50% female). Baseline demographics were similar. EVT patients showed superior outcomes: median ped-mRS at 3 to 6 months was 1 versus 2 (p = 0.015). EVT resulted in greater PedNIHSS reduction from admission to day 7 (-9 vs -1, p < 0.001) and lower PSOM at 3 to 6 months (0.5 vs 2.5, p = 0.009). This benefit persisted at 24 months with a median ped-mRS of 1 (IQR, 0-2) in the EVT group and 2 (IQR, 1-3) in the BMT group (p = 0.012). One symptomatic intracranial hemorrhage occurred in the BMT group, and no deaths or access-site complications were reported.

interpretationIn children with isolated M2 occlusion, EVT was associated with better functional outcomes and neurological recovery than medical therapy alone, with an acceptable safety profile. ANN NEUROL 2026;99:684-691.

Indexed as

Ischemic StrokeThrombectomyAdolescentChildChild, PreschoolCohort StudiesEndovascular ProceduresFemaleHumansInfantInfant, NewbornMaleRegistriesTreatment Outcome

Identifiers

PMID41316719
PMCPMC12954143

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.