Evidence map›Paper›PMID 41316726›Full record

ArticleNucleic acids research2026

VIRE: a metagenome-derived, planetary-scale virome resource with environmental context.

Suguru Nishijima, Anthony Fullam, Thomas S B Schmidt, Michael Kuhn, Peer Bork

Abstract read
In one paragraph

Article in Nucleic acids research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Suguru NishijimaMolecular Systems Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0002-8444-9272
Anthony FullamMolecular Systems Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0002-0884-8124
Thomas S B SchmidtAPC Microbiome and School of Medicine, University College Cork, Cork, Ireland.ORCID 0000-0001-8587-4177
Michael KuhnMolecular Systems Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0002-2841-872X
Peer BorkMolecular Systems Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany.ORCID 0000-0002-2627-833X

Funding

EMBLUehara Memorial Foundation 12/RC/2273-P2
6 · The paper itself

Abstract

Viruses are the most abundant biological entities on Earth, yet their global diversity remains largely unexplored. Here, we present VIRE, a comprehensive resource comprising over 1.7 million high- and medium-quality viral genomes recovered from >100 000 publicly available metagenomes derived from samples that cover diverse ecosystems, including host-associated, aquatic, terrestrial, and anthropogenic environments. Using a unified and scalable pipeline, we systematically assembled viral genomes and provided detailed information on genome completeness, taxonomic classification, predicted lifestyle, and host assignment based on CRISPR spacer matches. VIRE contains >89 million predicted viral open reading frames, as well as detailed functional annotations derived from multiple databases. Importantly, VIRE is seamlessly integrated with related microbiome resources such as SPIRE (https://spire.embl.de) and Metalog (https://metalog.embl.de), enabling users to jointly explore viral genomes, metagenome-assembled genomes, and associated environmental or clinical metadata. Accessible at https://vire.embl.de, VIRE provides an open-access, scalable platform for investigating viral diversity, evolution, and ecology on a planetary scale.

Indexed as

Databases, GeneticGenome, ViralMetagenomeViromeVirusesHumansMetagenomicsMicrobiotaMolecular Sequence AnnotationOpen Reading FramesSoftware

Identifiers

PMID41316726
PMCPMC12807717

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.