ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Payload-Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure-Function Relationships.
Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Stimulus-Responsive Polymeric Carriers for Gene Delivery: Balancing Endosomal Escape with Nucleic Acid Release.Pharmaceutical research · 2026Review
- Payload-Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure-Function Relationships.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Polymeric carriers are gaining increasing attention for the delivery of a range of clinically relevant nucleic acid (NA) payloads, due to their efficacy, safety, and modular chemistry. While the requirements for an "optimal" carrier depend strongly on the NA payload, research has largely centered on carrier properties rather than the unique needs of the payload. Therefore, in this review, a novel perspective inspired by protein structural organization is introduced to explore structure-function relationships of polymeric carrier systems, highlighting the diverse requirements of different NA payloads. To gain deeper mechanistic insights, the complicated polymer/NA delivery systems are deconvoluted into four hierarchical levels, including molecular composition, structural features, complexation, and 3D integration. In addition to outlining recent experimental strategies, it is emphasized that the structural diversity and tunability of polymer chemistry provide a foundation for payload-specific carrier design. Critical advances are expected in the molecular design of polymeric carriers to enhance NA delivery efficiency, improve biological safety and incorporate multifunctionality, particularly compared to lipid-based platforms that are currently ahead in clinical applications. A payload-specific design framework may guide development of next-generation polymeric carrier systems for basic research, biotechnology, and therapeutic applications.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.