ReviewMolecular biology reports2025
Molecular crosstalk for longevity: exercise and the AMPK/SIRT1/PGC-1α/Irisin/BDNF axis.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Metainflammation, Mitochondrial Dysfunction, and Organokine Crosstalk: A Central Axis Linking Metabolic Syndrome to Cardiovascular Diseases.International journal of molecular sciences · 2026Review
- Exercise-associated changes in leptin and irisin relate to cognitive function in older adults stratified by cognitive impairment.Scientific reports · 2026Article
- Exercise Improves Mitochondrial Homeostasis: A Potential Neuroprotective Strategy for Ischemic Stroke.Antioxidants (Basel, Switzerland) · 2026Review
- Impact of mechanical unloading on the irisin precursor, FNDC5, in skeletal muscle of sheep as a large animal experimental model.JBMR plus · 2026Article
- Mechanistic Modulation of Autophagy by Bioactive Natural Products: Implications for Human Aging and Longevity.Nutrients · 2026Review
- Synaptic Plasticity in Neurodegenerative Diseases: Impact of Exercise as Promising Therapeutic Tool.Cells · 2026Review
- Association between lower limb strength, anxiety, and depression symptoms in older adults.Revista da Associacao Medica Brasileira (1992) · 2026Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevention of age-related disorders is influenced by an intriguing combination of molecular pathways that can be activated through physical exercise. The molecules AMP-activated protein kinase (AMPK), Sirtuin 1 (SIRT1), peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), Irisin, and brain-derived neurotrophic factor (BDNF) are essential to this “anti-aging cycle” because they all support cellular function and maintenance in ways that may eventually delay or reverse the effects of aging even that partially or temporarily. AMPK is a master regulator of metabolism that has been connected to improved cellular repair processes and mitochondrial function. Additionally, it is becoming more well acknowledged that the protein deacetylase SIRT1 plays a significant role in regulating aging and age-related illnesses. It initiates several protective cellular processes by interacting with other longevity pathways, such as the production and release of PGC-1α and Irisin, which regulates mitochondrial biogenesis and function. Activation of the AMPK/SIRT1/PGC-1α/Irisin pathway and physical activity have been shown to regulate BDNF. This review aims to describe features of each component of this AMPK/SIRT1/PGC-1α/Irisin/BDNF pathway revealing how they can be stimulated through several mechanisms, including physical exercise, and how this activation acts as an anti-aging tool.
Indexed as
Identifiers
41317217What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.