Evidence map›Paper›PMID 41317957›Full record

ReviewJournal of advanced research2026

Arachidonic acid metabolism in spinal cord injury.

Xue Yao, Xinjie Liu, Wenbin Cai, Guangzhi Ning, Xu Zhang, Kailiang Zhou, Shiqing Feng

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xue YaoTianjin Key Laboratory of Spine and Spinal Cord, Tianjin Institute of Orthopeadic Innovation and Translation, International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, International Chinese Musculoskeletal Research Society Collaborating Center for Spinal Cord Injury, Tianjin 300052, China.
Xinjie LiuTianjin Key Laboratory of Spine and Spinal Cord, Tianjin Institute of Orthopeadic Innovation and Translation, International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, International Chinese Musculoskeletal Research Society Collaborating Center for Spinal Cord Injury, Tianjin 300052, China.
Wenbin CaiTianjin Key Laboratory of Metabolic Diseases, Department of Physiology and Pathophysiology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Center for Cardiovascular Diseases, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China.
Guangzhi NingTianjin Key Laboratory of Spine and Spinal Cord, Tianjin Institute of Orthopeadic Innovation and Translation, International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, International Chinese Musculoskeletal Research Society Collaborating Center for Spinal Cord Injury, Tianjin 300052, China.
Xu ZhangDepartment of Biophysics, School of Basic Medical Sciences, Peking University Health Science Center. State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100871, China. Electronic address: xuzhang@tmu.edu.cn.
Kailiang ZhouDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang Provincial Key Laboratory of Orthopedics, Wenzhou 325027, China. Electronic address: zhoukailiang@wmu.edu.cn.
Shiqing FengTianjin Key Laboratory of Spine and Spinal Cord, Tianjin Institute of Orthopeadic Innovation and Translation, International Science and Technology Cooperation Base of Spinal Cord Injury, Department of Orthopedics, Tianjin Medical University General Hospital, International Chinese Musculoskeletal Research Society Collaborating Center for Spinal Cord Injury, Tianjin 300052, China. Electronic address: sqfeng@tmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSpinal cord injury (SCI) initiates a cascade of secondary pathological processes significantly impairs functional recovery and leads to complications such as neuropathic pain. Arachidonic acid (AA) and its metabolites play crucial roles through various metabolic pathways. These pathways contribute to neuroinflammation, tissue damage, and functional impairment following SCI.

aimWe aim to provide a comprehensive outline on AA metabolic pathways, enzymes and signaling cascades in spinal cord injury pathophysiology, in order to develop new perspectives in treatment and diagnosis. KEY SCIENTIFIC CONCEPTS: We present a comprehensive review on AA metabolism and pathways in the different pathology process of SCI, such as neuronal loss, demyelination, neuropathic pain and neuroinflammation with different cell types involved. We also discussed the complex interactions of AA metabolites pose challenges for the development of effective therapies. Finally, we outlooked future research directions aimed at optimizing AA-targeted treatments and expanding their clinical applicability to enhance recovery in patients with SCI.

Indexed as

Arachidonic AcidSpinal Cord InjuriesAnimalsHumansMetabolic Networks and PathwaysSignal TransductionArachidonic AcidArachidonic acidCyclooxygenaseEicosanoidsEndocannabinoidsIsoprostanesLipoxygenaseSpinal cord injury

Identifiers

PMID41317957
PMCPMC13453892

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.