Evidence map›Paper›PMID 41318385›Full record

ArticleBMC plant biology2025

A chromosome-level genome assembly reveals triterpenoid biosynthesis in Clinopodium chinense.

Guohui Li, Mengda Wang, Muhammad Aamir Manzoor, Haiyu Wang, Junyi Cheng, Muhammad Arif, Yunpeng Cao, Jun Dai, Cheng Song

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Article in BMC plant biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Guohui LiEngineering Technology Research Center of Plant Cell Enginering, College of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an, Anhui Province, 237012, China.
Mengda WangEngineering Technology Research Center of Plant Cell Enginering, College of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an, Anhui Province, 237012, China.
Muhammad Aamir ManzoorNational Key Laboratory for Tropical Crop Breeding, School of Breeding and Multiplication (Sanya Institute of Breeding and Multiplication), Hainan University, Sanya, 572025, China.
Haiyu WangEngineering Technology Research Center of Plant Cell Enginering, College of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an, Anhui Province, 237012, China.
Junyi ChengCollege of Life Sciences, Sichuan University, Chengdu, Sichuan Province, 610064, China.
Muhammad ArifDepartment of Plant Protection, Faculty of agriculture, Sakarya University of Applied Sciences, Sakarya, Türkiye.
Yunpeng CaoState Key Laboratory of Plant Diversity and Specialty Crops, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan, 430074, China. xfcypeng@126.com.
Jun DaiEngineering Technology Research Center of Plant Cell Enginering, College of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an, Anhui Province, 237012, China. wxxydaijun@163.com.
Cheng SongEngineering Technology Research Center of Plant Cell Enginering, College of Biological and Pharmaceutical Engineering, West Anhui University, Lu'an, Anhui Province, 237012, China. lanniao812329218@163.com.

Funding

Anhui Innovation and Entrepreneurship Training Program for College Students S202510376030Anhui Provincial University Research Projects 2023AH052637Development of Big Data Integration and Analysis Platform for Traditional Chinese Medicine Genomics 0045025050ikou Science and technology planning project 2022-008Key research and development project of Hainan Province ZDYF2024SHFZ076Quality Engineering Project of Anhui Province 2024zybj032Quality Engineering Project of West Anhui University wxxy2024011Startup fund for high-level talents of West Anhui University WGKQ2021079
6 · The paper itself

Abstract

backgroundClinopodium chinense is an important medicinal plant in the family Lamiaceae. The desiccated roots of C. chinense possess various pharmacological activities and are widely used in traditional Chinese medicine.

resultsHere we present the first chromosome-level genome assembly of C. chinense, comprising 20 pseudochromosomes with a total size of 0.61 Gb and containing 45,466 predicted protein-coding genes. Genome evolution analyses indicated that two recent bursts of long terminal repeats (LTRs) significantly contribute to genome expansion in C. chinense. Additionally, numerous large-scale chromosomal rearrangements have been identified between the genomes of C. chinense and Thymus quinquecostatus. Comparative genomics analyses further indicated that tandem duplication may be one of the potential factors affecting the amplification of genes related to the synthesis pathway of and triterpenoid (including key metabolic nodes CYP and UGT genes). Subsequently, we identified several putative key genes involved in triterpenoid biosynthesis.

conclusionsOverall, this study gives new perspectives on the biosynthesis pathway of triterpenoids and lays a foundation for investigations into the genetic mechanism and medicinal properties of C. chinense.

Indexed as

Chromosomes, PlantGenome, PlantLamiaceaeTriterpenesEvolution, MolecularPlants, MedicinalTriterpenesC. chinenseComparative genomicsGenome assemblyTriterpenoids

Identifiers

PMID41318385
PMCPMC12756925

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.