Dual block evidence of the effects of topiramate, a sulfamate-substituted monosaccharide, on voltage-gated sodium current and hyperpolarization-activated cation current.

Ray-Chang Tzeng, Ming-Chi Lai, Sheng-Nan Wu, Chin-Wei Huang

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Article in BMC pharmacology & toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

4 authors.

Ray-Chang TzengDepartment of Neurology, Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation), Tainan, Taiwan.

Ming-Chi LaiDepartment of Pediatrics, Chi-Mei Medical Center, Tainan, Taiwan.

Sheng-Nan WuDepartment of Research and Education, An Nan Hospital, China Medical University, Tainan, Taiwan. snwu@mail.ncku.edu.tw.

Chin-Wei HuangDepartment of Neurology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. huangcw@mail.ncku.edu.tw.

Funding

National Science and Technology Council NSTC-111-2314-B-006-103-MY2, NSTC-112-2923-B-006-001, and NSTC-112-2320-B-006-034Tainan Municipal An-Nan Hospital ANHRF-112-42, ANAR-112-43, and ANHRF-112-44Tainan Municipal Hospital (Managed by Show Chwan Medical Care Corporation) RD-112012

6 · The paper itself

Abstract

backgroundTopiramate (TPM) is a sulfamate-substituted monosaccharide known for its wide-ranging effects on epilepsy, neuropathic pain, and migraines. However, its precise influence on plasmalemmal ionic currents, including their magnitude and gating kinetics, remains uncertain. Therefore, a reassessment of the regulatory effect of TPM on ionic currents in electrically excitable cells is warranted.

methodsWith the aid of patch clamp technology, we investigated the effects of TPM on the amplitude, gating, and hysteresis of plasmalemmal ionic currents from GH

resultsWe observed that TPM exhibited a concentration-dependent inhibition of both transient (I

conclusionsCollectively, these findings strongly suggest that TPM's effects on I

Indexed as

FructoseSodium ChannelsAnimalsDose-Response Relationship, DrugIon Channel GatingPatch-Clamp TechniquesRatsTopiramateFructoseSodium ChannelsTopiramateHyperpolarization-activated cation currentLate Na+ currentTopiramateTransient Na+ currentVoltage-gated Na+ current

Identifiers

PMID41318467

DOI10.1186/s40360-025-01043-6

PMCPMC12771823

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.