ArticleNature communications2025
Optimizing thiamine pyrophosphate metabolism enhances crop yield and quality.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed.
- Reconfiguring biofortification strategies to transform food systems and address micronutrient deficiency of the 21st century.Journal of integrative plant biology · 2026Review
- GhPsbO breaks the growth-immunity tradeoff by simultaneously promoting growth and defense in cotton.The Plant cell · 2026Article
- Achieving High-Density and Stress-Resilient Maize Breeding Via Germplasm Innovation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A TAF10-ERF109 Transcriptional Module Directs Flavonoid-Based Stress Resilience and Yield Enhancement in Foxtail Millet and Wheat.Plant biotechnology journal · 2026Article
- Global genetic dissection of maize-teosinte divergence reveals EL3-2 as a pleiotropic domestication regulator.Genome biology · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Global food security requires sustainable strategies to improve crop yield and nutrition. Although thiamine pyrophosphate (TPP), the active form of vitamin B1, plays a central role in energy metabolism, redox homeostasis, and carbon assimilation, its contribution to crop yield and quality remains largely unexplored. Here, we show that ZmTPK2, a thiamine pyrophosphokinase encoded by the major ear length QTL qKB6.2a, is a key regulator of maize yield. We reveal that ZmTPK2-dependent TPP homeostasis synchronizes three cornerstones of plant metabolism: mitochondrial tricarboxylic acid (TCA) cycle activity, chloroplast-mediated carbon fixation, and nitrogen utilization. Both overexpression and knockout of ZmTPK2 disrupt yield and grain quality, revealing that optimal TPP levels are required for productivity. Exogenous TPP supplementation increases grain yield in maize, rice, and rapeseed up to 9.8%. These findings identify TPP metabolism as a key regulatory pathway for metabolic engineering, biofortification, and global food security solutions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.