Evidence map›Paper›PMID 41318598›Full record

ArticleNature communications2025

Coherent X-rays reveal anomalous molecular diffusion and cage effects in crowded protein solutions.

Anita Girelli, Maddalena Bin, Mariia Filianina, Michelle Dargasz, Nimmi Das Anthuparambil, Johannes Möller, Alexey Zozulya, Iason Andronis, Sonja Timmermann, Sharon Berkowicz and 31 more

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Non-Fickian diffusion within assemblies of the intrinsically disordered protein β-casein.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Lipoprotein diffusion in dense yolk plasma is governed by softness, hydrodynamics, and caging: Insights from MHz-XPCS.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors.

Anita GirelliDepartment of Physics, AlbaNova University Center, Stockholm University, Stockholm, Sweden. anita.girelli@fysik.su.se.ORCID http://orcid.org/0000-0002-3872-2450
Maddalena BinDepartment of Physics, AlbaNova University Center, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4906-9335
Mariia FilianinaDepartment of Physics, AlbaNova University Center, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-1366-7360
Michelle DargaszDepartment Physik, Universität Siegen, Siegen, Germany.ORCID http://orcid.org/0009-0008-1925-9860
Nimmi Das AnthuparambilDepartment Physik, Universität Siegen, Siegen, Germany.ORCID http://orcid.org/0000-0001-5338-2004
Johannes MöllerEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.ORCID http://orcid.org/0000-0001-8363-9077
Alexey ZozulyaEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.ORCID http://orcid.org/0000-0003-1048-3432
Iason AndronisDepartment of Physics, AlbaNova University Center, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-5106-9348
Sonja TimmermannDepartment Physik, Universität Siegen, Siegen, Germany.ORCID http://orcid.org/0000-0002-5428-9044
Sharon BerkowiczDepartment of Physics, AlbaNova University Center, Stockholm University, Stockholm, Sweden.
Sebastian RetzbachInstitut für Angewandte Physik, Universität Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-5908-7823
Mario ReiserDepartment of Physics, AlbaNova University Center, Stockholm University, Stockholm, Sweden.
Agha Mohammad RazaDepartment Physik, Universität Siegen, Siegen, Germany.ORCID http://orcid.org/0000-0002-5783-3340
Marvin KowalskiDepartment Physik, Universität Siegen, Siegen, Germany.ORCID http://orcid.org/0000-0002-1610-4133
Mohammad Sayed AkhundzadehDepartment Physik, Universität Siegen, Siegen, Germany.
Jenny SchrageDepartment Physik, Universität Siegen, Siegen, Germany.
Chang Hee WooFakultät Physik/DELTA, TU Dortmund, Dortmund, Germany.
Maximilian D SenftInstitut für Angewandte Physik, Universität Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-0646-7918
Lara Franziska ReichartInstitut für Angewandte Physik, Universität Tübingen, Tübingen, Germany.
Aliaksandr LeonauDepartment Physik, Universität Siegen, Siegen, Germany.
Prabhu Rajaiah PrinceThe Hamburg Centre for Ultrafast Imaging, Hamburg, Germany.ORCID http://orcid.org/0000-0002-8312-0563
William ChèvremontESRF - The European Synchrotron, Grenoble, France.
Tilo SeydelInstitut Laue-Langevin, Grenoble, France.ORCID http://orcid.org/0000-0001-9630-1630
Jörg HallmannEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-1996-397X
Angel Rodriguez-FernandezEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.ORCID http://orcid.org/0000-0003-0587-5263
Jan-Etienne PudellEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.ORCID http://orcid.org/0000-0001-8268-444X
Felix BrausseEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.
Ulrike BoesenbergEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.
James WrigleyEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.ORCID http://orcid.org/0009-0003-6525-7413
Mohamed YoussefEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.ORCID http://orcid.org/0000-0002-3194-7411
Wei LuEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.
Wonhyuk JoEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.
Roman ShaydukEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.
Trey GuestEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.
Anders MadsenEuropean X-Ray Free-Electron Laser Facility, Schenefeld, Germany.ORCID http://orcid.org/0000-0001-6594-1029
Felix LehmkühlerThe Hamburg Centre for Ultrafast Imaging, Hamburg, Germany.ORCID http://orcid.org/0000-0003-1289-995X
Michael PaulusFakultät Physik/DELTA, TU Dortmund, Dortmund, Germany.
Fajun ZhangInstitut für Angewandte Physik, Universität Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0001-7639-8594
Frank SchreiberInstitut für Angewandte Physik, Universität Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-3659-6718
Christian GuttDepartment Physik, Universität Siegen, Siegen, Germany.ORCID http://orcid.org/0000-0002-0051-8542
Fivos PerakisDepartment of Physics, AlbaNova University Center, Stockholm University, Stockholm, Sweden. f.perakis@fysik.su.se.ORCID http://orcid.org/0000-0001-9863-9811

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-21-CE06-0047 IDPXNBundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 05K19PS1,05K20PSA,ErUM-Pro funding (05K22PS1)Bundesministerium für Bildung und Forschung (Federal Ministry of Education and Research) 05K19VTBCarl Tryggers Stiftelse för Vetenskaplig Forskning (Carl Trygger Foundation) CTS 21:1589Carl Tryggers Stiftelse för Vetenskaplig Forskning (Carl Trygger Foundation) CTS21:1589Deutsche Forschungsgemeinschaft (German Research Foundation) (DFG)-EXC 2056-project id no. 39071599Deutsche Forschungsgemeinschaft (German Research Foundation) SCHR700/28-1, SCHR700/42-1EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101081419EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020) 101081419 (PRISMAS) and 101149230 (CRYSTAL-X)Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation) WAF, Grant. No. 2023.0052Vetenskapsrådet (Swedish Research Council) 2019-05542, 2023-0533,2019-0607Wenner-Gren Foundation (Wenner-Gren Foundation for Anthropological Research, Inc.) Project No. UPD2021-0144
6 · The paper itself

Abstract

Understanding protein motion within the cell is crucial for predicting reaction rates and macromolecular transport in the cytoplasm. A key question is how crowded environments affect protein dynamics through hydrodynamic and direct interactions at molecular length scales. Using megahertz X-ray Photon Correlation Spectroscopy (MHz-XPCS) at the European X-ray Free Electron Laser (EuXFEL), we investigate ferritin diffusion at microsecond time scales. Our results reveal anomalous diffusion, indicated by the non-exponential decay of the intensity autocorrelation function g

Indexed as

FerritinsDiffusionHydrodynamicsSolutionsX-RaysFerritinsSolutions

Identifiers

PMID41318598
PMCPMC12669764

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.